Oxidative Stress in OR Personnel

Status Withdrawn

Clinical Trial Summary

The purpose of this study is investigate to the effect(s) of chronic occupational exposure to N20 and volatile anesthetics on the extent of oxidative stress (DNA damage and the generation of the biochemical markers) in operating room staff, with different levels of exposure to halogenated hydrocarbons, in comparison to unexposed controls (Intensive Care Staff), and to determine the relationship between the degree of oxidative stress and psychological stress, as assessed by validated psychometric measures.

Clinical Trial Description

This is a single blinded randomized, controlled and prospective clinical trial comparing oxidative stress status in two groups.

Subjects in two groups will be matched for gender, age, smoking habit and employment duration and will be randomized into one of the two groups of:

1. Pediatric OR Staff, and

2. control (e.g; ICU staff)

Biomarkers of oxidative stress will be measured in two different time points in each subject, (Monday Morning and, Friday afternoon of that same week->40 hours in Operating room or Intensive Care Unit).

The relationship between oxidative stress and psychological stress will also be assessed by validated psychometric measures. ;

Study Design

Related Conditions & MeSH terms

Oxidative Stress

Clinical Trial Details

NCT number	NCT02654834
Study type	Observational
Source	Nationwide Children's Hospital
Contact
Status	Withdrawn
Phase	N/A
Start date	May 2014
Completion date	March 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03255187` - Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution	N/A
Completed	`NCT04136821` - The Long-term Effects of Oceanix™ on Resistance Training Adaptations	N/A
Recruiting	`NCT03790345` - Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics	Phase 2/Phase 3
Completed	`NCT03358524` - Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia	Phase 4
Recruiting	`NCT05327348` - Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery	Phase 3
Completed	`NCT03288623` - The Effects of Dark Chocolate Implementation in Elite Athletes	N/A
Completed	`NCT04419025` - Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease	Phase 2
Completed	`NCT04597983` - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists	N/A
Not yet recruiting	`NCT06159543` - The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes	N/A
Enrolling by invitation	`NCT03030456` - Whole Body Vibrations on Functional Capacity, Muscular Strength, and Biochemical Profile in Elders	N/A
Not yet recruiting	`NCT02202239` - Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients	Phase 4
Completed	`NCT02256254` - SIMOX - Induction of Oxidative Stress	Phase 2
Recruiting	`NCT02048592` - Impact of Immunonutrition on the Patients With Cystic Fibrosis	Phase 4
Completed	`NCT01942460` - Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients	Phase 4
Completed	`NCT02463318` - The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects	N/A
Completed	`NCT01990391` - Brazil Nut Consumption in Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities	N/A
Completed	`NCT02177383` - Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance	N/A
Completed	`NCT00845130` - Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes	N/A
Completed	`NCT00607893` - Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea	N/A
Active, not recruiting	`NCT00247507` - The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients	Phase 4