Examining Endogenous Antioxidant Levels in Well Trained Cyclists

Oxidative Stress Clinical Trial

Official title:

The Effects of Habitual Antioxidant Supplementation on Endogenous Antioxidants and Oxidative Damage in Well Trained Cyclists

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02281851
• Other study ID #: 125663
• Secondary ID: 13/WM/0226
• Status: Completed
• Start date: July 2013
• Est. completion date: May 2016

Study information

• Verified date: August 2020
• Source: University of Birmingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will investigate whether increased habitual intake of antioxidant supplements effects the concentration of endogenous antioxidants, the response of antioxidants to exercise, and differences in oxidative damage compared to a non-supplemented group.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: May 2016
• Est. primary completion date: May 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Male,

• BMI 18.8 29.9 kg/m2

• cycle 3-7 times a week for durations longer than 60 minutes

• cycled for a minimum of 3 years

• accustomed to exhaustive cycling protocols

• healthy (no known cardiovascular or metabolic disease)

Exclusion Criteria:

• answering "NO" to any question on the general health questionnaire would result in exclusion from the study

• current participation in another clinical study

• current or recent smoker (last 30 days)

• prescription or non-prescription of anti-inflammatory use >30 days prior to the experiment commencing or any other medications that in the opinion of the investigator may interfere with redox signalling

Related Conditions & MeSH terms

• Oxidative Stress

Locations

Country	Name	City	State
United Kingdom	School of Sport Exercise and Rehabilitation Sciences, University of Birmingham	Birmingham	West Midlands

Sponsors (1)

Lead Sponsor	Collaborator
University of Birmingham

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Difference in Resting Levels of Endogenous Antioxidant Proteins in Skeletal Muscle - Superoxide Dismutase 2 (SOD-2)	To examine the effects of habitual vitamin and antioxidant supplementation on endogenous antioxidant production, participants will have a muscle biopsy taken at rest to examine any differences in endogenous antioxidant protein concentrations	Protein concentrations will be measured at baseline only