Vitamin E or Lipoic Acid on Serum Oxyphytosterol Concentrations

Status Active, not recruiting

Clinical Trial Summary

Background of the study:

We now know that plant sterols can oxidize, which results in the formation of oxyphytosterols. Animal studies have suggested that oxyphytosterols are atherogenic components, however this relation has not yet been studied in humans. In our previous study (METC 09-3-088) we have shown in healthy volunteers that serum oxyphytosterol concentrations are linked to oxidative stress status (i.e. we were able to identify high and low sterol oxidizers). From the literature is known that especially type II diabetics and IGT subjects are characterized by increased oxidative stress markers and reduced antioxidant capacity. For this reason we also want to evaluate the oxyphytosterol concentrations in this population. Moreover, we know propose to evaluate the effect of antioxidant supplementation, i.e. vitamin E or lipoic acid, on serum oxyphytosterol concentrations in type II diabetic patients. If possible to lower oxyphytosterol concentrations in these populations this is obviously beneficial in case oxyphytosterols turn out to be atherogenic. The major objective of the present study is to examine the effect of consuming vitamin E (804 mg) or lipoic acid (600 mg) for 4 weeks on fasting oxyphytosterol concentrations in subjects with impaired glucose tolerance or type 2 diabetes.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Oxidative Stress

Clinical Trial Details

NCT number	NCT01984567
Study type	Interventional
Source	Maastricht University Medical Center
Contact
Status	Active, not recruiting
Phase	N/A
Start date	April 2013
Completion date	January 2014

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03255187` - Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution	N/A
Completed	`NCT04136821` - The Long-term Effects of Oceanix™ on Resistance Training Adaptations	N/A
Recruiting	`NCT03790345` - Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics	Phase 2/Phase 3
Completed	`NCT03358524` - Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia	Phase 4
Recruiting	`NCT05327348` - Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery	Phase 3
Completed	`NCT03288623` - The Effects of Dark Chocolate Implementation in Elite Athletes	N/A
Completed	`NCT04419025` - Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease	Phase 2
Completed	`NCT04597983` - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists	N/A
Not yet recruiting	`NCT06159543` - The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes	N/A
Enrolling by invitation	`NCT03030456` - Whole Body Vibrations on Functional Capacity, Muscular Strength, and Biochemical Profile in Elders	N/A
Not yet recruiting	`NCT02202239` - Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients	Phase 4
Completed	`NCT02256254` - SIMOX - Induction of Oxidative Stress	Phase 2
Recruiting	`NCT02048592` - Impact of Immunonutrition on the Patients With Cystic Fibrosis	Phase 4
Completed	`NCT01942460` - Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients	Phase 4
Completed	`NCT02463318` - The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects	N/A
Completed	`NCT02177383` - Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance	N/A
Completed	`NCT01990391` - Brazil Nut Consumption in Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities	N/A
Completed	`NCT00845130` - Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes	N/A
Completed	`NCT00607893` - Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea	N/A
Active, not recruiting	`NCT00247507` - The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients	Phase 4