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NCT01141829 Clinical Trial

NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)

Oxidative Stress Clinical Trial

Official title:
NADPH Oxidase p22phox Polymorphisms and Oxidative Stress in Patients With Obstructive Sleep Apnea

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT01141829
Other study ID # NADPHPM2010
Secondary ID
Status Recruiting
Phase N/A
First received June 10, 2010
Last updated June 10, 2010

Study information
Verified date January 2010
Source Sociedad Española de Neumología y Cirugía Torácica
Contact Mónica de La Peña, MD
Phone 0034971175112
Email monica.delapena@ssib.es
Is FDA regulated No
Health authority Spain: Ministry of Health and Consumption
Study type Observational

Clinical Trial Summary

Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases. Several polymorphisms related to NADPH oxidase expression or NADPH oxidase activity has been identified. The investigators are going to compare the distribution of the allelic frequencies of A-930G and C242T polymorphisms and their possible relationship with the levels of 8-isoprostanes as a marker of oxidative stress in patients with OSA and in a control group without OSA.

Description:

DESIGN: CASE-CONTROL STUDY METHODS: We are going to determine the A-930G and C242T p22phox genotypes in patients with OSA and healthy subjects recruited from sleep unit of Son Dureta University Hospital, (Palma de Mallorca, Spain). 8-Isoprostane is going to be measured as an oxidative stress marker with an 8-isoprostane EIA kit (Cayman Chemicals Company, USA) in plasma samples.

Recruitment information / eligibility
Status Recruiting
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:Polyysomnografic study with Apnoea/Hypoapnoea Index higher to 10 in patients and lower in controls.

Exclusion Criteria:

- chronic obstructive pulmonary disease, liver cirrhosis, thyroid dysfunction, rheumatoid arthritis, chronic renal failure and/or psychiatric disorders.

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Spain Hospital Universitario Son Dureta Palma de Mallorca Baleares

Sponsors (2)
Lead Sponsor Collaborator
Sociedad Española de Neumología y Cirugía Torácica Spanish Research Center for Respiratory Diseases

Country where clinical trial is conducted

Spain, 

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