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NCT00721708 Clinical Trial

Pharmacokinetics of Carnosine

Oxidative Stress Clinical Trial

Official title:
Pharmacokinetics of Carnosine

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00721708
Other study ID # TMC/TUHS IRB 7737
Secondary ID
Status Completed
Phase N/A
First received July 22, 2008
Last updated December 14, 2009
Start date April 2007
Est. completion date July 2008

Study information
Verified date December 2009
Source Tufts University
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.

Recruitment information / eligibility
Status Completed
Enrollment 4
Est. completion date July 2008
Est. primary completion date October 2007
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 40 Years to 70 Years
Eligibility Inclusion Criteria:

- Healthy adult

- normal hematological parameters, normal serum albumin, normal liver function, normal kidney function

Exclusion Criteria:

- History of smoking or alcoholism

Study Design

Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• pure carnosine
one time dose of pure carnosine (450 mg)
Other:
• Beef
one time dose, 150 g of beef
• Chicken
One time dose, 150g of chicken breast
• Chicken broth
one time dose of chicken broth obtained from 150g of chicken breast

Locations
Country Name City State
United States Jean Mayer USDA-Human Nutrition Research Center on Aging at Tufts University Boston Massachusetts

Sponsors (1)
Lead Sponsor Collaborator
Tufts University

Country where clinical trial is conducted

United States, 

References & Publications (1)

Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini G. Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans. Amino Acids. 2010 Mar;38(3):847-58. doi: 10.1007/s00726-009-0291-2. E — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Plasma histidine-dipeptide 0, 30, 60, 100, 180, 240, & 300 min No
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