Ovulation Induction Clinical Trial
Official title:
The Application of a New Ovarian Stimulation Protocol in IVF: a Randomized Controlled Study
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It
can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles
growth evenly.
At present, standard gonadotropin releasing hormone analogue (GnRH-a) long protocol is used
in around 85% patients in the investigator's center. However, patients have to inject short
term GnRH-a 0.05mg or 0.1mg daily for around 3 weeks in one IVF cycle.
Long term GnRH-a, which is usually used in patients with endometriosis,has been shown to
increase IVF outcome by altering endometrial receptivity. Moreover, it is also very
convenient because patients do not have to inject GnRH-a daily. In order to make patients
feel more comfortable during IVF treatment, the investigators have used a new ovarian
stimulation protocol since the beginning of 2015. The investigators give patients long term
GnRH-a (3.75mg) once at menstrual cycle D2, and begin the use of Gn to stimulate follicle
growth around 30 days later based on the hormone levels and follicle size. In the pilot
observational study of several patients, no LH surge occurred during ovarian stimulation.
The aim of this randomized controlled study is to compare the efficiency of this new protocol
and standard GnRH-a long protocol in the investigator's center.
The primary outcome is ongoing pregnancy rate. Other parameters include number of oocytes retrieved, 2 pronucleus (2PN) fertilization rate, high quality embryo formation rate, implantation rate, spontaneous abortion rate, and ectopic pregnancy rate. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01008319 -
Traditional Clomiphene Citrate Administration vs. Stair-step Approach
|
Phase 3 | |
| Terminated |
NCT01075815 -
A Clinical Trial to Determine the Effect of Lutropin Alfa on Embryo Quality and Implantation Rate in Advanced Reproductive Age
|
Phase 2 | |
| Terminated |
NCT01079949 -
A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age
|
Phase 2 | |
| Completed |
NCT01081639 -
To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid Pen
|
Phase 3 | |
| Terminated |
NCT00697255 -
A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)
|
Phase 2 | |
| Completed |
NCT01183143 -
Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro Fertilization
|
Phase 3 | |
| Completed |
NCT01081626 -
Recombinant Follicle Stimulating Hormone (FSH) (Gonal-f®): Use in Ovulation Induction
|
Phase 4 | |
| Completed |
NCT01111084 -
A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α
|
N/A | |
| Completed |
NCT04834791 -
Letrozole Versus Gonadotropins in Clomiphene Citrate Resistance
|
Phase 4 | |
| Completed |
NCT01645241 -
Evolutive Potential of Embryos Obtained From Oocytes After Luteal Phase Ovarian Stimulation
|
N/A | |
| Terminated |
NCT04306692 -
Myo-inositol Versus Clomiphene Citrate in PCOS
|
Phase 4 | |
| Recruiting |
NCT03396380 -
Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome
|
Phase 3 | |
| Terminated |
NCT00823472 -
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
|
Phase 4 | |
| Completed |
NCT01110707 -
A Randomised, Phase II, Comparative Study With a Parallel Control for Evaluating the Efficacy and Safety of Combined Treatment of Lutropin Alpha and Recombinant Human Luteinizing Hormone in the Middle of the Controlled Ovarian Stimulation Follicular Phase in Women With Reduced Ovarian Reserve
|
Phase 2 | |
| Completed |
NCT04610957 -
Effect of Adding Isoflavonoids to Clomiphene Citrate for Ovulation Induction in Women With Polycystic Ovary Syndrome
|
N/A | |
| Completed |
NCT01185782 -
SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile Women
|
Phase 3 | |
| Terminated |
NCT00553514 -
AS900672-Enriched in Ovulation Induction
|
Phase 2 | |
| Completed |
NCT01152866 -
An Open Label, Canadian Phase IIIb Study With Ovidrel in Ovulation Induction (OI) and Assisted Reproductive Technique (ART)
|
N/A | |
| Not yet recruiting |
NCT03307720 -
Agonist Versus Classical HCG Trigger (Poor Responders, Normoresponders and High Responders)
|
N/A | |
| Completed |
NCT03825445 -
GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination.
|
N/A |