Anovulation Clinical Trial
Official title:
Traditional Clomiphene Citrate Administration Versus a Stair-Step Approach: A Randomized Controlled Trial
The purpose of this study is to compare the length of time to achieve ovulation and pregnancy
with a traditional protocol administration of clomiphene citrate versus a stair step
administration.
Our hypothesis is by using a stair-step approach in which a period is not induced between
administrations of escalating doses of clomiphene citrate, the time to ovulation and
pregnancy may be reduced.
The traditional administration of clomiphene citrate for ovulation induction involves taking
clomiphene citrate for 5 days. If ovulation does not occur within 14 days, a progestin pill
(such as Provera) is prescribed for 10 days to induce a period (which normally occurs within
1 week of stopping the pill). Then a higher dose of clomiphene citrate will be prescribed.
The stair-step administration of clomiphene citrate for ovulation induction also involves
taking clomiphene citrate for 5 days. In contrast, if ovulation does not occur within 7-9
days, a progestin pill (such as Provera) would NOT be taken to induce a period. The dose of
clomiphene will then be increased. Therefore, this would do away with the 10 days of taking
the progestin pill, and also do away with waiting for a period (usually 3 to 7 days) for a
total of up to a 20 day difference between clomiphene citrate dosing cycles.
;
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