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Overfeeding clinical trials

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NCT ID: NCT02211612 Completed - Obesity Clinical Trials

Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation

LIPOGAIN-2
Start date: September 2014
Phase: N/A
Study type: Interventional

To investigate metabolic and molecular response to fatty acid-specific overfeeding in overweight subjects, in relation to changes in ectopic fat, lean tissue mass and insulin sensitivity

NCT ID: NCT02145780 Completed - Overfeeding Clinical Trials

Polyphenols and Overfeeding

Poly-Nut
Start date: February 2014
Phase: N/A
Study type: Interventional

Obesity is a complex and multifactorial disease representing a major public health challenge. Indeed, overweight and obese people carry a major risk of developing insulin resistance and type 2 diabetes mellitus. It has been demonstrated that polyphenols could be used to counteract some of the mechanisms involved in the generation of insulin resistance. The model of overfeeding represents a very good study model of the metabolic complications of obesity, since it has been shown to induce a transient state of insulin resistance in the human. The purpose of this research is to study the effects of a overfeeding (+50% of daily caloric needs over 31 days) with or without polyphenols supplementation (2g/days over 31 days) on insulin sensitivity measured in the setting of a hyperinsulinemic euglycemic clamp and on post prandial partitioning of exogenous lipids after a test meal. During 31 days, the volunteers will consume chocolate bars, chips, chocolate breads and cola in addition to their usual diet and will be supplemented with 2g of grape polyphenols extract or with placebo.