Acute Myeloid Leukemia Clinical Trial
Official title:
Phase 0 Study for the Development of Immunological Assays for the Evaluation of WT-1, Survivin and HPV16 E7 Tumor Antigens Specific Immune Responses in Cancer Patients
This study is a clinical study aiming at establishing immunological assays for the
qualitative and quantitative evaluation of WT-1, Survivin and HPV16 E7-specific immune
responses in cancer patients. Such a study will allow the development of suitable
immunological tools to be used in assessing response in a subsequent phase I study aiming at
evaluating therapeutic vaccine candidates targeting WT-1, Survivin and/or HPV16
E7-expressing tumors. In addition, this study will help defining the baseline
cancer-associated immune responses in the selected patient population.
Cervical and ovarian cancer patients, as well as leukemia patients, will be included in this
study.
WT-1, Survivin and HPV-specific immune responses will be monitored in these patients by ex
vivo and cultured IFNg ELISpot as well as tetramer staining.
n/a
Observational Model: Case-Only, Time Perspective: Cross-Sectional
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