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Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI in Granulosa Cells

Infertility Clinical Trial

Official title:
Impact of FSH Dosage During Ovarian Stimulation for IVF/ICSI on the Expression of FSH- and LH-receptors in Granulosa Cells

Clinical Trial Summary

To study the influence of different daily rec-FSH dosages (150 IU versus 300 IU), performed in the same patient in consecutive cycles, on the relation between FSH- and LH-receptors of the granulosa cells of the growing follicle.

Clinical Trial Description

This is a prospective cross-over study. Investigators want to study the effect of different dosages of recombinant FSH in the same patient on the expression of the FSH- and LH-receptors in the granulosa cells and on the endocrine milieu in the blood and the follicular fluid. An improved understanding of the mechanism leading to progesterone elevation might initiate a change in the ovarian stimulation approach, thereby not only preventing progesterone elevation and its negative consequences on ART (Assisted Reproductive Technology) outcome, but also improving individualization of the ovarian stimulation treatment according to the patients' characteristics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05330130
Study type Interventional
Source ART Fertility Clinics LLC
Contact Barbara Lawrenz, PhD
Phone 026528000
Email barbara.lawrenz@artfertilityclinics.com
Status Recruiting
Phase Phase 1
Start date July 5, 2023
Completion date January 30, 2024
View Details
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