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NCT05576519 Clinical Trial

Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Epithelial Ovarian Carcinoma

Ovarian Carcinoma Clinical Trial

Official title:
Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Epithelial Ovarian Carcinoma

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05576519
Other study ID # Soh-Med-22-09-15
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 1, 2017
Est. completion date December 30, 2022

Study information
Verified date October 2022
Source Sohag University
Contact Nagwa Ahmed, Lecture
Phone 01017415996
Email nagwa.sadek@med.sohag.edu.eg
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Cancer stem cells (CSCs) can undergo self-renewal and differentiation. EpCAM is a 40-kDa type I transmembrane glycoprotein composed of a large extracellular domain, one transmembrane region, and a small intracellular domain of 26 amino acids. Recent insights revealed that it is involved in promoting cancer cell proliferation, migration, and invasiveness. It is used as a diagnostic and prognostic marker. EpCAM has also recently been identified as a marker for CSCs.

Description:

Ovarian carcinoma is one of most frequent cancer in women worldwide. Epithelial ovarian carcinoma is a group of neoplasms with different histologic pictures. Serous carcinoma is the most common type. Cancer stem cells (CSCs) can undergo self-renewal and differentiation. EpCAM is a 40-kDa type I transmembrane glycoprotein composed of a large extracellular domain, one transmembrane region, and a small intracellular domain of 26 amino acids. It is abundantly expressed by the majority of human epithelial carcinomas, including colorectal, breast, lung, prostate, ovarian, and endometrial cancers. it is overexpressed in various neoplasms. Recent insights revealed that it is involved in promoting cancer cell proliferation, migration, and invasiveness. It is used as a diagnostic and prognostic marker. EpCAM has also recently been identified as a marker for CSCs.

Recruitment information / eligibility
Status Recruiting
Enrollment 50
Est. completion date December 30, 2022
Est. primary completion date November 1, 2022
Accepts healthy volunteers
Gender Female
Age group N/A and older
Eligibility Inclusion Criteria: - Patients with epithelial ovarian carcinoma and underwent surgery Exclusion Criteria: - - Cases received pre-operative chemotherapy or radiotherapy. - Cases with insufficient clinical data.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Egypt Faculty of Medicine Sohag
Egypt Faculty of Medicine, Sohag University Sohag

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary evaluate EpCAM expression in ovarian carcinoma IHC 1 month
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