Ovarian Cancer Clinical Trial
Official title:
INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give
higher doses of chemotherapy and kill more tumor cells.
PURPOSE: Phase I/II trial to study the effectiveness of combination chemotherapy followed by
peripheral stem cell transplantation or bone marrow transplantation in treating patients who
have relapsed or recurrent germ cell cancer.
OBJECTIVES: I. Determine the response rate, overall survival, and disease-free survival of
patients with refractory or relapsed germ cell carcinoma treated with high-dose induction
chemotherapy comprising carboplatin and etoposide followed by autologous bone marrow or
peripheral blood stem cell rescue.
OUTLINE: Autologous peripheral blood stem cells (PBSC) or bone marrow is harvested. Patients
receive carboplatin IV continuously and etoposide IV over 1 hour on days -5 through -3.
Autologous PBSC or bone marrow is reinfused on day 0.
PROJECTED ACCRUAL: A maximum of 30 patients will be accrued for this study.
;
Primary Purpose: Treatment
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