Benefit of Hypothermia in OHCA Complicating AMI

Status Active, not recruiting

Clinical Trial Summary

To determine the clinical effectiveness of hypothermia treatment in patients with out-of-hospital cardiac arrest complicating acute myocardial infarction.

Clinical Trial Description

Out-of-hospital cardiac arrest (OHCA) is a leading cause of mortality worldwide. Due to significant improvement in the management of patients with OHCA, an increasing number of initially resuscitated patients are being admitted to hospitals. Nevertheless, OHCA remains associated with a poor prognosis, with a survival rate of approximately 8.8% to hospital discharge. Moreover, international registry data have indicated that favorable neurological outcome at hospital discharge or 30 days after OHCA is only 2.8-18.2% across all registries. The majority of adult cardiac arrest cases are associated with obstructive coronary artery disease. Thus, current guideline recommended that immediate angiography and primary revascularization in all patients with resuscitated cardiac arrest and ST-segment elevation on electrocardiography, and also in patients with resuscitated cardiac arrest without ST-segment elevation, but with high probability of acute coronary occlusion. However, even after prompt restoration of blood flow, a substantial proportion of patients with myocardial infarction (MI) experience extensive necrosis. The application of hypothermia in patients with acute MI focuses on the reducing energy consumption at cardiac level, a factor consistently linked to diminished infarction size in animal study. However, in a recent meta-analysis of randomized trials comparing different strategies for therapeutic hypothermia adjunctive to percutaneous coronary intervention (PCI) versus standard of care in patients with acute MI, faille to demonstrate clear benefit. It is important to note, however, these randomized trials were underpowered and as a results, they were unable to draw firm conclusions regarding the impact of therapeutic hypothermia. Therefore, this study aimed to investigate the impact of therapeutic hypothermia on clinical outcomes in patients who underwent primary PCI for acute MI after OHCA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06141252
Study type	Interventional
Source	Yonsei University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	November 15, 2023
Completion date	December 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05434910` - Blood Pressure and Cerebral Blood Flow After Cardiac Arrest	N/A
Active, not recruiting	`NCT03700125` - Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )	N/A
Completed	`NCT02527694` - CPR Quality Between Flexible Stretcher and Standard Stretcher in OHCA	N/A
Completed	`NCT02899507` - Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest	Phase 4
Recruiting	`NCT02184468` - Survival Study After Out-of-hospital Cardiac Arrest	N/A
Completed	`NCT04085692` - Dispatcher-Assisted CPR: Low-Dose, High-Frequency Simulation-Based Training	N/A
Recruiting	`NCT05029167` - REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)	N/A
Completed	`NCT04080986` - DOuble SEquential External Defibrillation for Refractory VF	N/A
Completed	`NCT04058925` - Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
Enrolling by invitation	`NCT05113706` - Does Bystanders Emotional State Influence Dispatcher-assisted Cardiopulmonary?Resuscitation
Completed	`NCT04219306` - Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls.	N/A
Completed	`NCT03881865` - P25/30 SSEPs and Neurological Prognosis After Cardiac Arrest
Recruiting	`NCT04993716` - Epidemiological Study on the Management of Out-of-hospital Cardiac Arrest Survivors in Champagne ArDEnnes
Completed	`NCT05062785` - Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants	Phase 1
Recruiting	`NCT06122337` - Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest
Not yet recruiting	`NCT04584463` - Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
Recruiting	`NCT03355885` - Early-onset Pneumonia After Out-of-hospital Cardiac Arrest	N/A
Recruiting	`NCT05132387` - Wroclaw Out-Of-Hospital Cardiac Arrest Registry
Not yet recruiting	`NCT05969028` - First Responder Airway & Compression Rate Trial	N/A
Not yet recruiting	`NCT06046339` - Left Ventricular Ejection Fraction in Cardiac Arrest Survivors Treated With Extracorporeal Cardiopulmonary Resuscitation

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Benefit of Hypothermia in OHCA Complicating AMI — Hypothermia

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms