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Otitis Media With Effusion clinical trials

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NCT ID: NCT06403319 Completed - Clinical trials for Otitis Media With Effusion

Otitis Media With Effusion and Type 2 Inflammation Diseases

Start date: January 1, 2009
Phase:
Study type: Observational

Otitis media with effusion (OME) is thought to be associated with comorbidities such as allergic rhinitis, gastroesophageal reflux disease, asthma, and more. Many of these comorbidities can be caused by type 2 inflammation (T2I). This study aims to characterize the risk of undergoing OME surgery. This retrospective, matched-cohort study involved the retrospective recruitment of patients from 2009 to 2020, using the Taiwan National Health Insurance Research Database (NHIRD)

NCT ID: NCT06256081 Completed - Clinical trials for Hearing Loss, Conductive

Testing a New App for Children With Glue Ear

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

To assess whether children with glue ear ( and some normal hearing controls) and their families find the Hear Glue Ear application acceptable and easy to use. Whether the hearing screening section on the app is comparable to the hearing test data obtained from formal audiology hearing tests.

NCT ID: NCT06100159 Completed - Quality of Life Clinical Trials

Short-term Effects of Ventilation Tubes in Children With Chronic Otitis Media With Effusion

Start date: January 20, 2017
Phase: N/A
Study type: Interventional

The goal of this clinical, randomized trial is to compare the sleeping patterns and quality of life of children with chronic otitis media with effusion (OME) with or without tympanic tubes insertion. The main questions it aims to answer are: - Does tympanic tube insertion have an effect on sleep quality in children with chronic OME? - Does tympanic tube insertion improve the quality of life for the children with chronic OME and their caregivers? Participants will have their movements during sleep and number of awakenings measured by an accelerometer placed on their wrist for 7 nights before and after tympanic tube insertion. Their caregivers will answer questionnaires regarding quality of life on behalf of the child. Researchers will compare with a control group of children who also is diagnosed with chronic OME. They will also have their sleep monitored for 7 nights and their caregivers will complete quality of life questionnaires, but the will not receive a tympanic tube. However the control group will be reassessed a month after baseline, and if they still qualify for tympanic tube insertion they will undergo the same routine as the intervention group.

NCT ID: NCT04395261 Completed - Clinical trials for Otitis Media With Effusion

Wideband Tympanometry in Otitis Media With Effusion

Start date: January 1, 2016
Phase:
Study type: Observational

The investigators asked the question if they can better estimate the middle ear status in OME that help them to decide between early intervention or longer follow up.

NCT ID: NCT03975842 Completed - Clinical trials for Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)

Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps

Start date: January 2010
Phase:
Study type: Observational

The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. A cross-sectional study of 80 consecutively presenting patients who were diagnosed with CRSwNP was conducted. The aim was to ascertain the prevalence of OME in CRSwNP patients, to determine whether the severity of CRSwNP affected OME, and to identify risk factors for OME in CRSwNP patients.

NCT ID: NCT03848026 Completed - Clinical trials for OTITIS MEDIA WITH EFFUSION

Tympanostomy Tube Extrusion Time & Viscosity

Start date: January 15, 2018
Phase:
Study type: Observational [Patient Registry]

Studies have focused on the factors that influence tympanostomy tube (TT) extrusion may contribute to the management of OME. In this study the investigators aimed to assess the correlation between the TT extrusion time and viscosity of the middle ear fluid. 33 patients scheduled for TT insertion included in the study. During the paracentesis, fluid from the middle ear was obtained, and the viscosity was measured with a viscometer. After the surgery, patients were controlled monthly until the tubes were seen extruded.The analysis of the correlation between tube extrusion time and viscosity was insignificant (p >0.05).

NCT ID: NCT03611842 Completed - Clinical trials for Otitis Media With Effusion

Study of the Expression of MMPs in OME in Children With Atrophy of the Eardrum

MMP and OME
Start date: September 30, 2018
Phase:
Study type: Observational

Metalloproteinases (MMPs) constitute a family of endopeptidases that cleaves the extracellular matrix as collagen included in the eardrum. Activity of MMP has been shown in some otitis media with effusion (OME) fluids. These enzymes could be directly linked to the prosnostic of OME as it may damage the eardrum and leads to tympanic atrophy. The main goal of the study is to find out the correlation between activity of MMPs and tympanic atrophy. The investigator will also study if there is any clinical predictive factors in relation to the level of MMPs.

NCT ID: NCT03590912 Completed - Clinical trials for Otitis Media With Effusion

Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion

Start date: September 5, 2018
Phase: Phase 4
Study type: Interventional

We intend to study the cost of treatment, efficacy and adverse effects for Otitis media with effusion.

NCT ID: NCT03323736 Completed - Clinical trials for AOM - Acute Otitis Media

In-Office Tympanostomy Tube Placement in Children (OTTER)

OTTER
Start date: October 31, 2017
Phase: Phase 3
Study type: Interventional

A prospective, single-arm, multicenter study to evaluate effectiveness and safety of Tymbion iontophoresis and tympanostomy tube placement using the Tula Iontophoresis and Tube Delivery Systems for children in an office setting.

NCT ID: NCT03277820 Completed - Probiotics Clinical Trials

Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion

Start date: April 3, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to investigate whether the microbiota in the upper respiratory tract (nasopharynx, adenoids and middle ear fluid) of otitis media with effusion (OME) patients is changed after 4 weeks of probiotic product intake. Therefore, bacterial DNA from swabs, fluid and tissue will be isolated via commercially available DNA extraction kits, followed by Illumina MiSeq sequencing in order to identify the bacterial species present in these samples. Furthermore, the concentration of specific pathogens will be monitored via qPCR.