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Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning

Weaning From Mechanical Ventilation Clinical Trial

Official title:
Role of Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning From Mechanical Ventilation

Clinical Trial Summary

The aim of this study is to assess the validity of the diaphragmatic thickening Fraction measured by ultrasound as a predictor for successful weaning from mechanical ventilation.

Clinical Trial Description

Timing is critical for proper weaning for patients undergoing mechanical ventilation; if this is performed prematurely complications can include increased cardiovascular and respiratory stress, CO2 retention and hypoxemia. However, unnecessary delay in weaning can also cause a number of side-effects.Weaning outcomes have been assessed by several indices. Variables such as minute ventilation, Pao2/Fio2, rapid shallow breathing index and static compliance have all been used, with variable predictive values. Previous studies have proved that diaphragmatic dysfunction is one of the main etiologies of difficult weaning, because the diaphragm progressively weakens with mechanical ventilation.Methods used to assess diaphragm function, such as fluoroscopy, phrenic nerve stimulation, measurement of trans-diaphragmatic pressure and dynamic magnetic resonance imaging of the diaphragm, all have limitations. These include ionizing radiation exposure, low availability, invasiveness and necessity for patient transportation. Conversely, the use of ultrasound is safe, non-invasive, avoids radiation side-effects, and is available at the bedside.The aim of this study is to assess the validity of the diaphragmatic thickening Fraction measured by ultrasound as a predictor for successful weaning from mechanical ventilation. ;

Study Design

Related Conditions & MeSH terms

  • Weaning From Mechanical Ventilation
Clinical Trial Details
NCT number NCT06465082
Study type Observational [Patient Registry]
Source Mansoura University Hospital
Contact Mohamed AbdElmoniem
Phone 01014008473
Email dr.m1993@mans.edu.eg
Status Recruiting
Phase
Start date June 5, 2024
Completion date November 15, 2024
View Details
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