| Eligibility |
Inclusion Criteria:
1. Patients volunteered to participate in this study after full informed consent and
signed a written informed consent form;
2. Aged 18-75 years old;
3. Pathologically confirmed ovarian epithelial cancer, epithelial fallopian tube cancer,
or primary peritoneal cancer;
4. International Federation of Gynecology and Obstetrics (FIGO) 2018 edition staging
III-IV;
5. Having received no more than 2 prior lines of platinum-containing chemotherapy and = 6
months between the time of last chemotherapy and tumor recurrence;
6. No more than 1 prior PARP inhibitor;
7. Negative for germline breast cancer susceptibility gene(BRCA) mutations;
8. At least 1 measurable lesion according to RECIST 1.1 evaluation criteria;
9. Patients with expected survival of =12 weeks;
10. Have an Eastern Cooperative Oncology Group(ECOG) Performance Status(PS) score of 0-1;
11. The patient has good organ function: without having received transfusions of blood
products, granulocyte colony-stimulating factor, interleukin 11, thrombopoietin, or
thrombopoietin receptor agonists within 14 days prior to the first receipt of
therapeutic agents in this regimen:
- Neutrophil count =1.5 x 10^9/L.
- platelet count = 80 × 10^9/ L.
- hemoglobin =75 g/L.
- albumin =30 g/L.
- Albumin =30 g/L
- Total bilirubin = 1.5 times the upper limit of normal (ULN)
- Alanine amino transferase(ALT), Aspartate amino transferase(AST) = 3 times ULN
(without liver metastases) or = 5 times ULN (if liver metastases occur)
- Serum creatinine =1.5 times upper limit of normal (ULN)
- Requirements for coagulation: international normalized ratio (INR) =1.5 times
ULN, prothrombin time (PT) =1.5 times ULN, activated partial thromboplastin time
(APTT) =1.5 times ULN.
- Corrected serum electrolytes within normal range;
12. Women of childbearing potential must have had a negative pregnancy test (serum or
urine) within 7 days prior to enrollment and be willing to use an appropriate method
of contraception for the duration of the trial and for 8 weeks after the last
administration of the test drug.
Exclusion Criteria:
1. Known hypersensitivity or severe allergic reactions to the study drug or any of its
excipients;
2. Concurrent other incurable malignancies;
3. The presence of uncontrolled or symptomatic active central nervous system (CNS)
metastases;
4. Pregnancy or confirmed by blood or urine Human Chorionic Gonadotropin(HCG) test or
lactation, or subjects of childbearing potential who are unwilling or unable to use
effective contraception (for both male and female subjects) until at least 6 months
after the last trial treatment;
5. Difficult-to-control diabetes mellitus (defined as high fluctuations in blood glucose
that interfere with the patient's life as well as frequent hypotension despite
standard insulin therapy and frequent blood glucose monitoring);
6. Myocardial infarction, severe/unstable angina pectoris, New York Heart
Association(NYHA) class 2 or greater cardiac insufficiency, clinically significant
supraventricular or ventricular arrhythmias and symptomatic congestive heart failure,
uncontrolled hypertension of moderate or greater severity (Systolic Blood Pressure
>160 mm Hg or Diastolic Blood Pressure >100 mm Hg) within 4 weeks prior to the first
study dose, known coronary artery disease, congestive heart failure that does not meet
the above criteria congestive heart failure or left ventricular ejection fraction <50%
that meets the above criteria must be treated with an optimally stabilized medical
regimen as determined by the treating physician and, if appropriate, in consultation
with a cardiologist;
7. Patients with a history of neurologic autoimmune disease, or moderate to severe
autoimmune disease, or high doses of immunosuppressive agents for symptom control
8. History of known allogeneic organ transplantation or allogeneic hematopoietic stem
cell transplantation
9. Receipt of any of the following medications or treatments prior to the first study
drug treatment
1. major surgery within 6 weeks (tissue biopsies and Peripherally Inserted Central
Catheter or infusion port implantation via peripheral venous puncture for
diagnostic purposes are permitted)
2. Requires ongoing high-dose systemic corticosteroids (>10 mg/day prednisone or
equivalent dose of other medications) or other systemic immunosuppressants
(including, but not limited to, cyclophosphamide, azathioprine, methotrexate,
thalidomide, tacrolimus, cyclosporine, meclofenamic acid esters, anti-thymocyte
globulin, and anti-tumor necrosis factor medications), and continues to be
required after enrollment; [Note]: Topical skin, ocular, intra-articular,
intranasal, and inhaled corticosteroids are permitted .
10. Serious infections within 90 days, such as severe pneumonia requiring hospitalization,
bacteremia, and co-infections; active tuberculosis; [Note 1] Hepatitis B Surface
Antigen Positive (HBsAg+) and/or Hepatitis B Core Antibody Positive (HBcAb+) patients
will be required to undergo a Hepatitis B Virus Deoxyribonucleic Acid (HBV DNA) test,
if the HBV DNA copy number <1000 cps/mL, or less than the lower limit of detectable
value of the research center, can participate in this study and regulate the use of
anti-hepatitis B virus medication; [Note 2] patients with hepatitis C antibody
positive (HCV Ab+) need to undergo HCV RNA testing, and HCV RNA negative (defined as
less than the lower limit of detectable value of the research center) can participate
in this study;
11. Psychiatric disorders that interfere with informed consent and/or protocol adherence;
12. Other conditions that, in the judgment of the investigator, make participation in this
study inappropriate.
|
