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NCT06236945 Clinical Trial

HUTT to Assess Cardiac Autonomic Nervous Function

Autonomic Nervous System Diseases Clinical Trial

Official title:
Composite Autonomic Scoring Scale and HUTT to Assess Cardiac Autonomic Nervous Function: A Preliminary Study

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06236945
Other study ID # 20230213
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date January 31, 2024
Est. completion date December 31, 2025

Study information
Verified date December 2023
Source The First Hospital of Hebei Medical University
Contact Yan Ding, M.D.
Phone 18633889260
Email dingding13001300@126.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Autonomic nervous system diseases can cause abnormalities in the circulatory system, leading to malignant arrhythmia and sudden cardiac death. Standardized, operable, and simplified diagnostic indicators are urgently needed to evaluate autonomic nervous function, particularly cardiac autonomic nervous function. The investigators use HUTT in order to provide data support for cardiac autonomic nervous system evaluation.

Description:

In this study, 169 samples with vertical tilt test and 24-h Holter ECG data from February 13, 2023 to October 31, 2023 were selected. The AC, DC, and 24-h HRV were compared with the CASS to identify the indicators with the strongest correlation with the CASS sympathetic and vagus nerve scores. The best index was selected, and the score intervals were delimited. The sensitivity and specificity of the defined vagal and sympathetic intervals were analyzed.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 169
Est. completion date December 31, 2025
Est. primary completion date December 31, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 12 Years to 85 Years
Eligibility Inclusion Criteria: - Vertical tilt test and 24-hour holter electrocardiogram were performed at the same time - Receive treatment in our hospital. Exclusion Criteria: - Taking benzodiazepines or hypotensive drugs within 24 hours - Combined with mental illness, severe dementia, serious organ disease - Severe arrhythmia, deep breathing and poor coordination of Valsaval movements affected the interpretation of results.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
The First Hospital of Hebei Medical University

Outcome
Type Measure Description Time frame Safety issue
Primary To find the indicators which are most correlated to the sympathetic and vagus nerves. The investigators use HUTT and CASS score to find some indicators which are most correlated to the sympathetic and vagus nerves,so that can give data support to the clinical treatments February 13, 2023 to December 31, 2025
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