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Clinical Trial Summary

The goal of this phase 2 trial is to test the safety and efficacy of azacitidine when given together with PD-1 therapy in treating patients with relapsed/refractory classic Hodgkin lymphoma.


Clinical Trial Description

The investigators will evaluate response rate, progression free survival (PFS), overall survival (OS), and toxicity of azacytidine combined with PD-1 therapy in classic relapsed/refractory Hodgkin lymphoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06190067
Study type Interventional
Source Navy General Hospital, Beijing
Contact Liren Qian, PhD
Phone +861066947192
Email qlr2007@126.com
Status Recruiting
Phase Phase 2
Start date October 30, 2023
Completion date December 2028

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05518318 - GLS-010 Monotherapy Versus Chemotherapy in Patients With Relapsed or Refractory Classical Hodgkin's Lymphoma (R/R cHL) Phase 3
Recruiting NCT02408861 - Nivolumab and Ipilimumab in Treating Patients With HIV Associated Relapsed or Refractory Classical Hodgkin Lymphoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery Phase 1
Recruiting NCT05039073 - Brentuximab Vedotin and Nivolumab for the Treatment of Relapsed/Refractory Classic Hodgkin Lymphoma Previously Treated With Brentuximab Vedotin or Checkpoint Inhibitors Phase 2
Suspended NCT01896999 - Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma Phase 1/Phase 2
Active, not recruiting NCT04788043 - Study of Magrolimab and Pembrolizumab in Relapsed or Refractory Classic Hodgkin Lymphoma Phase 2
Active, not recruiting NCT04074746 - Modified Immune Cells (AFM13-NK) and A Monoclonal Antibody (AFM13) in Treating Patients With Recurrent or Refractory CD30 Positive Hodgkin or Non-Hodgkin Lymphomas Phase 1/Phase 2
Active, not recruiting NCT03150329 - Pembrolizumab and Vorinostat in Patients With Relapsed or Refractory DLBCL, FCL or HL. Phase 1
Recruiting NCT05162976 - CC-486 and Nivolumab for the Treatment of Hodgkin Lymphoma Refractory to PD-1 Therapy or Relapsed Phase 1
Completed NCT00967369 - Combination Chemotherapy With or Without Bortezomib in Treating Patients With Classical Hodgkin Lymphoma That Has Returned or Does Not Respond to Prior Treatment. Phase 2
Withdrawn NCT05711628 - A Trial Comparing Chemotherapy Versus Novel Immune Checkpoint Inhibitor (Pembrolizumab) Plus Chemotherapy in Treating Relapsed/Refractory Classical Hodgkin Lymphoma Phase 3
Active, not recruiting NCT02595866 - Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer Phase 1