Bortezomib-based Regimen for Refractory or Relapsed Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia, in Relapse Clinical Trial

Official title:

Bortezomib-based Regimen for Refractory or Relapsed Acute Lymphoblastic Leukemia in Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06034561
• Other study ID #: 4009/23
• Status: Recruiting
• Phase: Phase 2
• Start date: April 1, 2024
• Est. completion date: August 2029

Study information

• Verified date: March 2024
• Source: Instituto do Cancer do Estado de São Paulo
• Contact: Graziela S Silva
• Phone: 551138934677
• Email: graziela.sasilva[@]hc.fm.usp.br
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a interventional phase II study aiming to examine the complete response rate of a bortezomib-based salvage regimen in adults with refractory or relapsed acute lymphoblastic leukemia (ALL), seeking to compare outcomes with the available literature and with our historical data on relapsed/refractory ALL.

Description:

Acute lymphoblastic leukemia (ALL) is a rare neoplasm in adults, with long-term survival rates approaching 50% with current regimens. Although high rates of complete response are achieved with the first-line therapy, many patients are primary refractory or may further relapse. Arguably, these patients have a more resistant disease with higher risk genetic alterations and a much less likely to be cured, which almost always only can be obtained by a following allogeneic hematopoietic stem-cell transplantation (HSCT). Therefore, strategies to salvage patients with detectable disease after induction blocks or with relapsed disease are crucial to prolong survival and potentially cure those patients, working as a bridge therapy to HSCT. Historically, patients with relapsed/refractory ALL have received multidrug regimens based on high-dose cytarabine, such as fludarabine, cytarabine and idarubicin (FLAG-IDA). Those regimens provide a 30-40% complete response rate with non-negligible toxicity. Recently, new targeted agents such as blinatumomab, inotuzumab, and cellular therapies have arisen for B-lineage disease, even though these agents are not available in the public health setting. Previous studies have tested salvage regimens for ALL encompassing proteasome inhibitors plus highly synergistic drugs (dexamethasone, vincristine, asparaginase, doxorubicin), with exciting outcomes in limited case series. For adults, these regimens are less studied. However, preliminary data suggest that they are less toxic and more potent since patients can receive different drug combinations that they had not been exposed to before. The primary objective of this study is to examine the complete response rate of this regimen in our population, aiming to compare with the available literature and with our historical data on relapsed/refractory ALL. Secondary objectives are:

1. To determine the safety and feasibility of a bortezomib-based regimen for salvage relapsed/refractory ALL in our setting.

2. To determine the rate of patients who are able to proceed with HSCT after the treatment.

3. To calculate event-free survival and overall survival after the salvage regimen for relapsed/refractory ALL.

4. To calculate the rate of measurable residual disease (MRD) negative status after the treatment.

5. To examine the rate of febrile neutropenia, liver toxicity, neurotoxicity, and treatment-related mortality after this regimen in relapsed/refractory ALL.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: August 2029
• Est. primary completion date: August 2028
• Accepts healthy volunteers: No
• Gender: All
• Age group: 16 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients between 16 and 60 years-old with refractory or relapsed ALL (=1% of anomalous blasts by flow cytometry in bone marrow or peripheral blood) after one or two lines of therapy, regardless of their phenotype or baseline genetic alteration;

• Patients are eligible after allogeneic HSCT as long as patients are not actively being treated for graft-versus-host-disease (GvHD).

Exclusion Criteria:

• Burkitt leukemia;

• Prior myeloproliferative disease;

• Drug allergies;

• Eastern Cooperative Oncology Group (ECOG) scale >2;

• Total bilirubin>2x upper limit of normal (ULN);

• Transaminases>5x ULN;

• Creatinine>2,5 mg/dl;

• Active uncontrolled infection;

• History of asparaginase-induced pancreatitis;

• Prior exposure to bortezomib;

• Heart failure New York Heart Association (NYHA) Class III or IV;

• Patients with more than 400mg/m2 lifetime exposure of anthracycline;

• Severe psychiatric disorder which prevents adequate compliance;

• Refusal to participate in the study.

Related Conditions & MeSH terms

• Acute Lymphoblastic Leukemia With Failed Remission
• Acute Lymphoblastic Leukemia, in Relapse
• Leukemia
• Leukemia, Lymphoid
• Precursor Cell Lymphoblastic Leukemia-Lymphoma

Intervention

Drug:
• Bortezomib
Patients should receive one or two courses of this regimen, aiming to achieve complete remission as a bridge to proceed with allogeneic HSCT.

Locations

Country	Name	City	State
Brazil	Instituto do Cancer do Estado de Sao Paulo	São Paulo	SP

Sponsors (2)

Lead Sponsor	Collaborator
Instituto do Cancer do Estado de São Paulo	Libbs Farmacêutica LTDA

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Complete response	Disappearance of lymphoid blasts in peripheral blood, with fewer than 5% of lymphoid blasts quantified in the bone marrow aspirate through immunophenotyping.	30 days
Secondary	Event-free survival	Time interval between study enrollment and the occurrence of an event (non-response, relapse, or death) or last follow-up (censorship).	1 year
Secondary	Overall survival	Time interval between study enrollment and the occurrence of death or last follow-up (censorship).	1 year
Secondary	Rate of MRD-negativity	Absence of pathological lymphoid blasts in a bone marrow sample detected through immunophenotyping with a minimum sensitivity of 10-4.	60 days
Secondary	Rate of allogeneic hematopoietic stem-cell transplantation	Proportion of patients who successfully underwent allogeneic hematopoietic stem-cell transplantation after the study therapy	1 year