Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia

Patients Undergoing Elective Craniotomy Clinical Trial

— TIVA  

Official title:

Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia for Patients Undergoing Craniotomy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06031883
• Other study ID #: 685-2023
• Status: Recruiting
• Phase: Phase 1/Phase 2
• Start date: February 1, 2023
• Est. completion date: April 1, 2024

Study information

• Verified date: March 2024
• Source: Minia University
• Contact: Eron Ashraf Faried
• Phone: 01066197115
• Email: roneashraf20[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Efficacy of adding low dose ketamine or fentanyl to propofol-dexmedetomidine as total intravenous anesthesia for patients undergoing craniotomy in supra tentorial brain tumor

Description:

Efficacy of adding low dose ketamine or fentanyl to propofol-dexmedetomidine as total intravenous anesthesia for patients undergoing craniotomy in supra tentorial brain tumor surgery on brain relaxation score, hemodynamics, surgeon satisfaction score , total requirement of intra operative propofol and post operative analgesia

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 40
• Est. completion date: April 1, 2024
• Est. primary completion date: April 1, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients aged 18-70 years old ASA I - III with GCS 14-15 and BMI<35 scheduled for elective craniotomy for resection of supratentorial masses

Exclusion Criteria:

• Patients will be excluded if they will refuse to give a written consent. Also patients with GCS < 14 or having endocrine or blood diseases or sever cardiac disease or sever liver disease or renal failure and patients with uncontrolled hypertension or uncontrolled diabetes mellitus and patients have allergy to any of the study drugs.

Related Conditions & MeSH terms

• Patients Undergoing Elective Craniotomy

Intervention

Drug:
• Ketamine
Total intravenous anesthesia in craniotomy

Locations

Country	Name	City	State
Egypt	Eron	Minya

Sponsors (2)

Lead Sponsor	Collaborator
Minia University	Minia University Hospital

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Evaluation of brain relaxation score	1:perfectly relaxed , 2:satisfactory relaxed , 3:firm brain and 4:bulging brain	Intraoperative