Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT05922072 |
Other study ID # |
KingEdwarMU |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
June 3, 2021 |
Est. completion date |
December 3, 2021 |
Study information
Verified date |
June 2023 |
Source |
King Edward Medical University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting
duration without the risk of aspiration of gastric contents during elective pediatric
procedures under general anesthesia.
Description:
Pre-operative fasting is a specific time period before a procedure in which participants will
be advised not to take any liquid or solid by mouth. Nil per oral (NPO) is a universally
accepted practice before elective general anesthesia in order to reduce gastric contents
aspiration. In the period of chloroform anesthesia NPO was introduced because of vomiting and
discomfort associated with anesthesia. Hence prevention from aspiration of gastric contents
was a main focus during general anesthesia. With introduction of better anesthesia drugs
recommendations were given to keep minimal fasting time before general anesthesia.
Recent guidelines suggest six, four and two hours fasting for solids/ infant formula milk,
breast milk and clear fluids respectively. It is common practice to keep children NPO for 6
hours before surgery. But many times, children have to suffer excessive unnecessary fasting
due to delayed surgery that lead to reduction in systolic blood pressure, induce catabolic
state and behavioral effects. Moreover prolonged fasting increases insulin resistance and may
increase the inflammatory response to surgery.