Clinical Trials Logo
  1. Home
  2. Other
  3. NCT05892055

Brain Mechanisms of Attention and Pain in Youth With FAPD

Functional Abdominal Pain Syndrome Clinical Trial

Official title:
Brain Mechanisms of Attention and Pain in Youth With Functional Abdominal Pain Disorders

Clinical Trial Summary

The objectives of this study are to identify neural mechanisms of increased pain in pediatric FAPD and examine mechanisms of disrupted attention in the presence of induced pain. The overarching goal is to determine whether youth with FAPD process pain differently than healthy youth and to identify the brain areas involved.

Clinical Trial Description

The goal of the current project is to enhance understanding of the neural mechanisms associated with the pain experience in youth with functional abdominal pain disorders (FAPD), which is the most common and debilitating presentation of FAPD. This study will examine the neural mechanisms associated with pain induction and diminished attentional regulation during pain in FAPD. Findings from pilot studies indicate that increased anxiety in FAPD is associated with higher pain-related impairment, and that anxiety may adversely impact response to a cognitive behavioral intervention for pain. While pain outcomes improve when anxiety is also addressed in treatment for FAPD, a sizable portion fail to respond to currently available interventions. Further, the PI found that induced pain in FAPD is associated with changes in regional brain activity and functional connectivity between brain regions that are implicated in chronic pain. It is crucial to better understand the neural mechanisms which may place youth with FAPD at risk for poorer outcomes in order to ultimately develop more effective treatments. In this study, neural mechanisms of response to a pain symptom provocation task in youth with FAPD will be compared to healthy controls. The impact of anxiety levels will also be explored. This study will also examine neural mechanisms associated with disrupted attentional regulation during pain induction in youth with FAPD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05892055
Study type Observational
Source Michigan State University
Contact
Status Withdrawn
Phase
Start date February 28, 2019
Completion date March 28, 2019
View Details
See also
  Status Clinical Trial Phase
Suspended NCT04069572 - Vibratory Stimulation for the Treatment of Chronic Pain N/A
Completed NCT02565355 - Targeted Food Elimination for Treatment of Functional Gastrointestinal Diseases in Children N/A
Recruiting NCT05491499 - Assessing the Impact of Exercise Based Intensive Interdisciplinary Pain Treatment (IIPT) on Endogenous Pain Modulation in Youth With Chronic Pain Syndromes
Recruiting NCT05486585 - i-CBT Functional Gastrointestinal Disorders in Youth: the Impact of Negative Illness Understanding and Parental Illness Worries N/A
Recruiting NCT05945251 - ICBT for Children With FAPDs - the Child's Pain Regulation
Recruiting NCT05799053 - Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study Phase 3
Recruiting NCT05814497 - Supraspinal Processing of Sensory Aspects of Pain N/A
Active, not recruiting NCT05636358 - Hypnotherapy Through Self-exercises in Children With Functional Abdominal Pain in Primary Care N/A
Completed NCT02030392 - A Randomized-controlled Study of a Cognitive-behavioral Intervention for Children With Functional Abdominal Pain N/A
Recruiting NCT06310733 - The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders Phase 4
Recruiting NCT02613078 - Hypnotherapy vs. Probiotics in Children With IBS and Functional Abdominal Pain N/A
Completed NCT03078634 - The Multi-disciplinary Treatment of Functional Gut Disorders Study N/A
Recruiting NCT06268964 - Exploring Treatments for Children's Abdominal Pain: Comparing Trimebutine and Probiotics Phase 1/Phase 2
Withdrawn NCT04619095 - Reducing Pain and Anxiety Through Dietary Fiber Supplementation in Children With Abdominal Pain N/A
Completed NCT03771027 - Therapeutic Effect of the Low FODMAP Diet in Children With Functional Abdominal Pain. N/A
Completed NCT03518216 - Neural Mechanisms of Treatment Response to ADAPT N/A
Completed NCT03134950 - Improving Care for Youth With FAP: A Stepped Care CBT Delivery Approach N/A
Completed NCT03931330 - Does Improving Vagal Tone Increase Mitochondrial Bioenergetics N/A
Recruiting NCT03823742 - Do Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program? N/A
Not yet recruiting NCT04320550 - Frequency of Functional Gastrointestinal Disorders in Children