Updated 06/21/2024

A Trial of HRS-1893 in Healthy Volunteers and Patients With Obstructive Hypertrophic Cardiomyopathy

Obstructive Hypertrophic Cardiomyopathy Clinical Trial

Official title:
A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effects of Food on the Pharmacokinetics of HRS-1893 Tablets After Single and Multiple Ascending Oral Doses in Healthy Volunteers and Patients With Obstructive Hypertrophic Cardiomyopathy

Status Recruiting

Clinical Trial Summary

The purpose of this phase Ⅰ study is to evaluate the safety, tolerability and pharmacokinetics of HRS-1893 in healthy volunteers and patients with obstructive hypertrophic cardiomyopathy

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Cardiomyopathies
Cardiomyopathy, Hypertrophic
Hypertrophy
Obstructive Hypertrophic Cardiomyopathy

Clinical Trial Details

NCT number	NCT05879523
Study type	Interventional
Source	Shandong Suncadia Medicine Co., Ltd.
Contact	Xiaoyi Sun
Phone	+86 0518-82342973
Email	xiaoyi.sun@hengrui.com
Status	Recruiting
Phase	Phase 1
Start date	June 5, 2023
Completion date	June 2024

See also
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	Active, not recruiting	`NCT03723655` - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM	Phase 2/Phase 3
	Completed	`NCT04603521` - Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)
	Active, not recruiting	`NCT06211595` - Feasibility Study of the DragonFire for Hypertrophic Obstructive Cardiomyopathy	N/A
	Recruiting	`NCT06116968` - An Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCM	Phase 3
	Completed	`NCT03470545` - Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy	Phase 3
	Not yet recruiting	`NCT06146660` - A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy
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	Recruiting	`NCT06224621` - Percutaneous Endocardial Septal Radiofrequency Ablation in Obstructive Hypertrophic Cardiomyopathy	N/A
	Completed	`NCT01631006` - Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic Cardiomyopathy	N/A
	Not yet recruiting	`NCT06368037` - Feasibility Study of the DragonFire for Hypertrophic Obstructive Cardiomyopathy	N/A
	Recruiting	`NCT05489705` - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive HCM)
	Completed	`NCT06354556` - Effect of Verapamil Tablets on the Pharmacokinetic of HRS-1893 Tablets in Healthy Subjects	Phase 1
	Completed	`NCT04783766` - Safety, Tolerability and Pharmacokinetics Study of CK-3773274	Phase 1