Clinical Trials Logo

Clinical Trial Summary

Premature atrial contractions (PACs) and premature ventricular contractions (PVCs) are observed in the majority of individuals monitored for more than a few hours. Although the clinical course of PACs and PVCs is usually benign, it has been described that high PAC or PVC frequency causes various comorbidities and worsens outcomes in different patient groups. For example, PACs can initiate episodes of atrial fibrillation, and PAC count is highly specific in predicting diagnosis of incident atrial fibrillation. Increasing PVC frequencies are an important predictor of incident heart failure. While conventional wisdom dictates that common environmental exposures determine PAC and PVC frequencies, this has not born out in rigorous studies. Whether PAC and PVC frequencies may have genetic underpinnings remains unknown. Comparisons between identical twins and fraternal twins can provide estimates of heritability. Fraternal twins are an ideal control because, like identical twins, they share a womb, have the same birthday, and their environment while growing up are as similar as between identical twins. However, while identical twins share approximately 100% of the same inherited DNA, fraternal twins share, on average, about 50%. By monitoring identical and fraternal twins with portable electrocardiograms (ECGs), we will be able to count the PACs and PVCs over a consecutive timespan to describe the familial aggregation of these complexes. This, to our knowledge, would be the first study to compare PAC and PVC frequencies in identical and same-sex fraternal twins, providing the first assessment of how genetical inheritance may influence cardiac ectopy burdens.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05866731
Study type Observational
Source University of California, San Francisco
Contact Grace Wall
Phone 415-562-5906
Email grace.wall@ucsf.edu
Status Recruiting
Phase
Start date March 22, 2022
Completion date January 1, 2025

See also
  Status Clinical Trial Phase
Completed NCT03370679 - The Prognostic Significance of Premature Ventricular Complexes in Patients Without Structural Heart Disease N/A
Completed NCT04884100 - enHEART - Exploring Full Content of Optical Signals to Enhance Cardiac Arrhythmia Screening N/A
Not yet recruiting NCT04990089 - VIVO European Observational Registry
Not yet recruiting NCT06110364 - Vagal Nerve Stimulation as an Alternative Therapy for Premature Ventricular Contractions Phase 3
Completed NCT04171479 - RMN Versus Manual Epicardial Retrospective PMCF
Not yet recruiting NCT04519112 - Remote Magnetic Versus Manual Navigation-guided Ablation for Non-outflow Tract Premature Ventricular Contractions: a Prospective, Randomized, Controlled Trial Phase 4
Recruiting NCT01235156 - Efficacy and Safety of Sulcardine Sulfate Tablets in Patients With Premature Ventricular Contractions Phase 2
Recruiting NCT04909528 - LLTS to Treat Premature Ventricular Contractions N/A
Not yet recruiting NCT06327425 - MCG for Localization of Tachyarrhythmia's Origin N/A
Completed NCT03340142 - VIVO™ Accuracy Study N/A
Completed NCT05008250 - Efficacy and Safety of Metoprolol Tartrate Tablets Combined With Chinese Traditional Medicine on Premature Ventricular Complex. Phase 4
Completed NCT02666742 - DOACs for Stroke Prevention Post Ventricular Tachycardia Ablation Phase 4
Completed NCT03447002 - Urine Levels of Metanephrin and Normetanephrin in Patients With Frequent Ventricular Premature Complex
Withdrawn NCT04219501 - Ventricular Arrhythmia Ablation With the Use of Non-Invasive ECG Imaging Technology N/A
Not yet recruiting NCT03086902 - Comparision of PVC Ablation Techniques N/A
Recruiting NCT05341544 - Non-invasive Vagal Stimulation for Frequent Premature Ventricular Complexes N/A
Enrolling by invitation NCT01750775 - Shensongyangxin Capsule in the Treatment of Sinus Bradycardia With Premature Ventricular Contractions Phase 4
Completed NCT05167058 - Electrocardiographic Diagnostic Performance of the Apple Watch Augmented With an Artificial Intelligence Algorithm
Terminated NCT03288766 - SHERLOCK 3CG™ Diamond Tip Confirmation System