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Clinical Trial Summary

The purpose of this research study is to find out what effects (the good and bad) the combination treatment of metformin and CPI-613 has in treating participants with acute myeloid leukemia or granulocytic sarcoma that has either returned after treatment or did not respond to treatment.


Clinical Trial Description

Primary Objective: To establish the feasibility of delivering the combination of CPI-613 and metformin in patients with relapsed or refractory acute myeloid leukemia (AML). Secondary Objectives: To determine the response rate of CPI-613 and metformin in relapsed or refractory AML defined as Complete remission (CR) + Complete remission with incomplete count recovery (CRi) + Morphologic Leukemia-Free State (MLFS). - To determine the overall survival of patients with relapsed or refractory AML treated with CPI-613 and metformin. - To determine the safety of CPI-613 and metformin in patients with relapsed or refractory acute myeloid leukemia (AML). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05854966
Study type Interventional
Source Wake Forest University Health Sciences
Contact Study Coodinator
Phone 336-716-5440
Email bpowell@wakehealth.edu
Status Not yet recruiting
Phase Phase 2
Start date July 2024
Completion date September 2025

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