Arterial Blood Gases in Weaning of Mechanical VEntilation

Weaning of Mechanical Ventilation Clinical Trial

— WAVE  

Official title:

Arterial Blood Gases in Weaning of Mechanical VEntilation

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05801692
• Other study ID #: CHUB WAVE
• Status: Active, not recruiting
• Start date: December 21, 2022
• Est. completion date: October 1, 2023

Study information

• Verified date: January 2023
• Source: Centre Hospitalier Universitaire de Besancon
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Weaning of mechanical ventilation is an important phase of ICU (Intensive Care Unit) patient hospitalization. Patients have to pass a spontaneous breathing trial, can have a phase of pause with mechanical ventilation before extubation and then can be weaned of invasive mechanical ventilation. Spontaneous breathing trial can be performed with a T-Tube or with Pressure support without PEEP (End Expiratory Positive Pressure) . Duration of spontaneous breathing trial range from 30 minutes to 120 minutes. Some clinicians performed an arterial blood gases at the end of the spontaneous breathing trial but this practice is not really defined and clearly explained in recommendations. Patients can benefit of ventilation support after extubation like non invasive pressure support or high flow nasal canulae. The procedure can be very different from a center to another, especially for arterial blood gases at the end of spontaneous breathing trial. Our aim is to observe in a multicenter study the daily practice of weaning of mechanical ventilation especially for arterial blood gases.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 100
• Est. completion date: October 1, 2023
• Est. primary completion date: July 1, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Older than 18 years

• first attempt of weaning of mechanical ventilation

Exclusion Criteria:

• withholding of life sustaining therapies

• spontaneous breathing trial unsuccessful

Related Conditions & MeSH terms

• Weaning of Mechanical Ventilation

Intervention

Procedure:
• Weaning of mechanical ventilation
Weaning of mechanical ventilation is the time when the patient is ready for separation from ventilatory support until breathing without invasive support

Locations

Country	Name	City	State
France	BARROT	Besançon

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Besancon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Type of spontaneous breathing trial performed	Spontaneous breathing trial is performed either with pressure support or with a T-Piece	In the 24 hours of spontaneous breathing trial
Secondary	Arterial blood gases at the end of spontaneous breathing trial	Arterial blood gases are sometime performed at the end of the spontaneous breathing trial during weaning of mechanical ventilation. Spontaneous breathing trial takes from 30 to 120 minutes	In the hour of spontaneous breathing trial
Secondary	Duration of spontaneous breathing trial	Duration in minutes	The day of the spontaneous breathing trial
Secondary	Ventilatory procedure at the end of spontaneous breathing trial: either immediate extubation or pressure support ventilation with intubation	the procedure at the end of spontaneous: the patient is either extubated immediately or benefit of about one hour of invasive pressure support with the settings before spontaneous breathing trial until extubation. Procedure of extubation is differed of about one hour.	The day of extubation if extubation performed
Secondary	Frequency and type of ventilatory support after extubation	Ventilatory is either not performed or if performed, with pressure support or high flow oxygen nasal canulae	The day of extubation if extubation performed
Secondary	Need for reintubation	Reintubation is the need to reintubate the patient because of extubation failure	During the seven days following extubation
Secondary	Etiology of reintubation	The cause of reintubation (pulmonary edema, infectious pulmonary disease...)	During the seven days following extubation
Secondary	Death	If the patient died	The first 28 days following extubation
Secondary	Ventilator associated pneumoniae	Pneumoniae acquired after more than 48 hours of mechanical ventilation	From 48 hours after extubation until extubation
Secondary	days alive without mechanical ventilation	The number of days without invasive mechanical ventilation support during the first 28 days of intensive care hospitalization.	during the first 28 days of intensive care hospitalization.