A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment — NAITIVE  

Poor Response to Ovulation Induction Clinical Trial

Official title: A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment,

Status Recruiting

Clinical Trial Summary

Study investigates the effect of four-dimensional patient data (medical, lifestyle, environmental, and genetic) on the outcomes of ovarian stimulation for IVF.

Study will allow us to create a meaningful combination of medical knowledge, unique physician experience and information derived from data analysis. Additionally, the Study allows us to fine-tune the existing algorithms and develop new decision-supporting algorithms.

Clinical Trial Description

Details of the ovarian stimulation and its outcomes for each patient will be analysed with the corresponding patient data collected or generated during the Study in the five streams as described under the headings "Stream one" to "Stream five".

Stream one: Personal and medical data Patient mobile app - collects up to 227 different data points about the female and additional up to 64 data points about her partner, Appendix 13.

Physician portal - mirrors the patient data from the mobile app and will provide tools for physician decision-making support and for error minimisation during the treatment using algorithms.

Stream two: Biorhythms and lifestyle Devices monitoring activity and health data (smart watches, bracelets, rings)

1. Heart rate

2. Respiratory rate

3. Heart rate variability

4. Blood oxygen level

5. Sleeping cycle

6. Sleeping respiratory rate

7. Body temperature

8. Activity - steps

9. Stress level

Stream three: Environment

Based on patient location(s), the following data are monitored:

1. Season

2. Weather

3. Moon phases

4. Sun activity

5. Pollution

Stream four: Biomarkers Blood tests - the hormonal profile is determined at the beginning of the menstrual cycle and some determinations are made on the day of ovulation induction (trigger)

1. anti-mullerian hormone

2. follicle stimulating hormone

3. luteinizing hormone (also on the trigger day)

4. Oestradiol (also on the trigger day)

5. Prolactin

6. Progesterone (also on the trigger day)

7. thyroid-stimulating hormone (TSH)

8. antibody thyroid peroxidase

9. sex hormone-binding globulin

10. Testosterone

11. DHEAS

Follicular fluid (FF)

1. Examination of oxidative stress level a. Total oxidant status, Appendix 14 b. Total antioxidant capacity, Appendix 14

2. Proteomic analysis, Appendix 15

3. Amino acids analysis, Appendix 15

4. Lipidaemic analysis, Appendix 15

5. Metabolomic analysis, Appendix 15

Cumulus cells (CCs) a) Telomere length and telomere activity analysis, cell viability score, Appendix 16

Embryonic culture media (ECM)

a) Embryonic DNA analysis by Next Generation Sequencing (NGS), Appendix 17 b) Embryonic microRNA analysis, Appendix 17 Stream five: Genetic study of FSH-receptor and polycystic ovary syndrome polymorphisms

1. Polymorphisms of gene receptors influencing the response to ovarian stimulation by Next-Generation Sequencing (NGS) a. follicle-stimulating hormone receptor

2. Gene polymorphisms in polycystic ovary syndrome patients a. CYP11A1 b. CYP17A1 c. CYP19A1 ;

Related Conditions & MeSH terms

• Poor Response to Ovulation Induction

• NCT number: NCT05780632
• Study type: Observational
• Source: Cognitive IVF a.s.
• Contact: Jan Choma, MS
• Phone: 00420 602 575 666
• Email: jan.choma@leeaf.life
• Status: Recruiting
• Start date: April 3, 2023
• Completion date: March 2025