Clinical Trials Logo

Clinical Trial Summary

Mitral regurgitation (MR) for degenerative disease is nowadays routinely treated with valve repair with excellent short and long term results in experienced centers. However, repair durability can varies according to the characteristics of the initial lesion, and better long term durability in isolated lesions of the posterior leaflets compared to anterior or bi-leaflets prolapse has been shown. A commissural MR can be caused by lesions of the anterior, posterior or both leaflets and several surgical techniques have been proposed to treat these lesions. However, long term outcomes of mitral valve repair (MVr) for isolated commissural flail or prolapse remain poor defined. In San Raffaele Hospital cardiac surgery, commissural lesions are usually treated with a functional approach, by means of edge-to-edge approximation of the anterior and posterior leaflet at the commissural area (commissural closure). The investigators previously reported the short and mid-term outcomes of this technique with satisfactory results. With this study the investigators aim to analyze the very long term clinical and echocardiographic results of isolated commissural lesions treated with commissural closure.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05774769
Study type Observational
Source Ospedale San Raffaele
Contact
Status Completed
Phase
Start date October 9, 2021
Completion date October 19, 2021

See also
  Status Clinical Trial Phase
Not yet recruiting NCT03290872 - Mitral Annuloplasty Rings RCT N/A
Completed NCT05836532 - Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causing Degenerative Mitral Regurgitation
Completed NCT05839782 - Long Term Results in Redo Mitral Valve Surgery After Mitral Valve Repair
Recruiting NCT03706833 - Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial N/A
Recruiting NCT05655897 - Safety and Efficacy of the GeminiOne Transcatheter Valve Edge-to-Edge Repair System in Patients With Moderate-severe or Severe Degenerative Mitral Regurgitation N/A
Enrolling by invitation NCT04734756 - Safety and Effectiveness Study of Dragonfly System for Degenerative Mitral Regurgitation N/A
Enrolling by invitation NCT04067635 - Primary Mitral Regurgitation Repair
Active, not recruiting NCT06021509 - Clinical Study of NovoClasp for Treating Moderate to Severe and Severe Degenerative Mitral Regurgitation N/A
Not yet recruiting NCT04679662 - EXPLORE DMR: Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation N/A
Active, not recruiting NCT04281940 - Chordal Repair for Transcatheter Mitral Valve Repair (TMVr) N/A
Not yet recruiting NCT05417945 - A Prospective, Multicenter Study to Evaluate the JensClip Transcatheter Valve Repair System N/A
Recruiting NCT03433274 - Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation N/A
Active, not recruiting NCT03674593 - Clinical and Fundamental Aspects of Prosthetics and Translocation of Mitral Valve Chordae N/A
Recruiting NCT05595226 - Effect of RT3D-TEE-guided Mitral Valve Repair on Outcomes in Patients With Degenerative Mitral Valve Disease N/A
Terminated NCT04666480 - Early Feasibility Study of the PLAR Implant and Delivery System to Treat Degenerative Mitral Regurgitation N/A