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Neuropathy and Anti-GFAP Antibodies — Neuro-GFAP  

Neurological Diseases or Conditions Clinical Trial

Official title:
Study of the Consequences of Anti-GFAP Antibodies on the Peripheral Nervous System

Clinical Trial Summary

Anti-Glial Fibrillary Acidic Protein (GFAP) are antibodies associated to inflammatory diseases of the central nervous system. The GFAP protein is highly expressed by astrocytes explaining these syndromes, but GFAP is also expressed by immature and non-myelinating Schwann cells. Thus, these antibodies could also lead to damages of the peripheral nervous system (PNS). Moreover, such damages have already been reported on small studies, and there is a need for larger cohorts. The investigators will use the cohort of patients with neurological syndromes and anti-GFAP antibodies identified in the cerebrospinal fluid (CSF) of the "Reference center for paraneoplastic neurological syndromes and autoimmune encephalitis" to determine the frequency of the PNS involvement in these patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05742087
Study type Observational
Source Hospices Civils de Lyon
Contact
Status Active, not recruiting
Phase
Start date September 1, 2022
Completion date May 1, 2023
View Details
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