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NCT05695053 Clinical Trial

Low Level Laser Therapy Applied in Orthodontic Tooth Movement

Orthodontic Appliance Complication Clinical Trial

Official title:
Low Level Laser Therapy Applied in Orthodontic Tooth Movement

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05695053
Other study ID # CMUH110-REC2-138
Secondary ID
Status Recruiting
Phase Early Phase 1
First received
Last updated
Start date August 27, 2021
Est. completion date August 26, 2023

Study information
Verified date January 2023
Source China Medical University Hospital
Contact Jian-hong Yu, doctor
Phone +886 422053366
Email kenkoyu@mail.cmu.edu.tw
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Currently, orthodontic treatment takes 2-3 years.. If we accelerate tooth movement by low energy laser therapy, we could reduce treatment time. Low Level Laser Therapy(LLLT) applied in Orthodontic Tooth Movement, which stimulates formation of osteoclast-like cells expression in vitro. Osteoclast can be served as an index for tooth movement. Increasing the number of osteoclast will increase bone formation and tooth movement. We plan to find a useful clinical protocol to improve the efficiency of orthodontic tooth movement. Test low energy laser in vitro. Find an effective wavelength and irradiation time to stimulate formation of osteoclast. Develop an useful protocol that clinical orthodontist could follow and reduce orthodontic treatment time.

Recruitment information / eligibility
Status Recruiting
Enrollment 20
Est. completion date August 26, 2023
Est. primary completion date August 26, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patients with good oral hygiene - 18 years old - Patients who required bilateral canine retraction into the extracted premolar Exclusion Criteria: - Serious medical history - Poor oral hygiene - Previous orthodontic treatment - Orthognathic surgery or syndromic patients

Study Design

Related Conditions & MeSH terms

  • Orthodontic Appliance Complication

Intervention

Device:
• Low Level Laser Therapy
Low level laser therapy could provide energy to trigger cell differentiation.
Other:
• Placebo
Placebo

Locations
Country Name City State
Taiwan China Medical University Hospital Taichung City

Sponsors (1)
Lead Sponsor Collaborator
China Medical University Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Farivar S, Malekshahabi T, Shiari R. Biological effects of low level laser therapy. J Lasers Med Sci. 2014 Spring;5(2):58-62. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Orthodontic tooth movement the distance between canine and premolar 1-6month
Secondary bone density after Orthodontic tooth movement bone density change around canine 1-6month
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