Muscle Function Clinical Trial
Official title:
The Impact of Bed Rest and Aging on Muscle Mass and Muscle Function: Effects of Neuromuscular Electrical Stimulation
Loss of muscle mass is common phenotypic trait of muscular disuse and ageing. The loss of muscle mass affects, among others, the ability to maintain homeostasis of glucose metabolism and the energy reservoir in catabolic conditions, while also affecting mechanical muscle function which can cause detrimental impairments in general functional status and hence quality of life. However, a limited amount of research has attempted to elucidate molecular regulators of muscle mass loss following bed rest in older individuals and across genders. Consequently, the mechanistic drivers are unresolved and there are currently no effective therapeutic strategies to counteract muscle wasting and loss of function in individuals submitted to bed rest e.g. during hospitalization. Purpose The purpose is to examine the effects of 5 days of bed rest on muscle mass, including myofibrillar protein synthesis and breakdown, and muscle function, and elucidate molecular regulators of muscle mass loss and metabolic pathways, while also investigating if potential negative effects can be counteracted by daily NeuroMuscular Electrical Stimulation (NMES) across different age and genders. Methods The study is designed as a randomized controlled cross-over 5-day bed rest study including a group of healthy young (18-30 years) and healthy old (65-80 years) men and women. Participants will receive daily electrical stimulation (NMES) of the thigh muscles (30 min x 3/day) on one leg (ES), while the other leg serves as a control (CON). Participants will be tested at baseline (pre) and after (post) intervention for muscle strength, muscle power, balance, and muscle activation. Blood samples are collected at several time points and muscle biopsies are sampled pre- and post-intervention along with assessment of whole-body muscle mass and thigh muscle mass. Scientific exposition The results from the study can potentially provide insight into the adaptive mechanisms associated with NMES training and muscular disuse on both cellular- and whole-body level. The understanding of the underlying mechanisms is crucial for the application of NMES in a therapeutic context and will furthermore help us understand the basic mechanism regulating the skeletal muscle mass during both training and muscular disuse. Overall, the results can potentially help establishing treatments to counteract loss of muscle mass, muscle function and muscle health during periods of muscular disuse.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04300504 -
Muscle in Obesity: Imaging, Function and microRNA
|
||
| Completed |
NCT01825616 -
Vitamin D2, Muscle Damage, NASCAR Pitcrew
|
N/A | |
| Recruiting |
NCT06379282 -
Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia
|
N/A | |
| Completed |
NCT02991989 -
Does Exercise Snacking Improve Muscle Function in Older Adults?
|
N/A | |
| Recruiting |
NCT06067477 -
Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups
|
N/A | |
| Completed |
NCT05929118 -
The Effect of Aquatic Rehabilitation on Knee Function in Anterior Cruciate Ligament Reconstruction Patients.
|
N/A | |
| Completed |
NCT05397418 -
Female Muscle Enhancement
|
N/A | |
| Not yet recruiting |
NCT04241497 -
Home-based Exercise Training in Patients With Pulmonary Arterial Hypertension: Effect on Skeletal Muscular Function and Metabolism
|
N/A | |
| Completed |
NCT03956732 -
Effects of Milk Protein and Vitamin D on Children's Growth and Health
|
N/A | |
| Completed |
NCT02655393 -
A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
|
Phase 1 | |
| Completed |
NCT04563611 -
Effect of Exercises on Hamstring Muscle Function, Injury Risk, Agility and Cognitive Function
|
N/A | |
| Completed |
NCT02858882 -
Vitamin D Status and Muscle Function
|
N/A | |
| Completed |
NCT03283462 -
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
|
N/A | |
| Completed |
NCT02819505 -
β-alanine Supplementation on Knee Extensor Contractile and Force Properties
|
Phase 4 | |
| Completed |
NCT02317536 -
A Pilot Clinical Trial on the Efficacy of Two Carnitine-Based Products on Muscle Function in Healthy Older Adults
|
Phase 2 | |
| Suspended |
NCT03111979 -
The Effects of 4 Week β-alanine Supplementation on Knee Extensor Contractile and Force Properties in the Over 60s
|
Phase 4 | |
| Recruiting |
NCT04619784 -
Effect of Pilates Application on Abdominal Muscle Function, Core Stability, Musculoskeletal Pain, Quality of Life, Anxiety and Depression in Parkinson's Patients
|
N/A |