Other Clinical Trial - Topical Timolol 0.5% in Atrophic Acne Scar

Status Not yet recruiting

Clinical Trial Summary

The aim of the study is to evaluate the efficacy and safety of microneedling combined with topical timolol 0.5% in the treatment of atrophic acne scars.

Clinical Trial Description

Acne vulgaris (AV) is a common chronic inflammatory disease of skin that develops from sebaceous glands associated with hair follicles. Typically AV begins at puberty and may continue through adulthood affecting the comedogenic areas of face, back and chest (Mazzetti et al., 2019). One of the undesirable outcomes of acne is acne scars that are divided into two main types based on a loss (atrophic) or gain (hypertrophic) of collagen. Atrophic type is the most common type, further subdivided into three subtypes: icepick, boxcar and rolling scar (Bahl et al., 2020). Post acne scars occur in nearly 75% of patients with acne affecting both male and female equally (Khunger and Kumar, 2012). Acne scars impair quality of life and may be a risk factor for depression, suicide, low academic performance and unemployment (Sood et al., 2020). There are different therapeutic modalities for atrophic acne scars including microneedling, chemical peeling, laser, filler, surgical procedures (punch excision, punch grafts) and fat transfer (Pavlidis and Katsambus, 2017). Microneedling is considered safe for all skin types. It is performed by dermapen or dermaroller to induce new collagen formation that remains for a few months after the procedure (Cohen and Elbuluk, 2016). Microneedling enhances the effect of topical preparations when used combined with them due to increasing their absorption by creating small channels through the epidermis to the dermis (Jaffe, 1981). Ghassemi et al. (2021) observed that application of 0.5% timolol after TCA-CROSS caused a slight increase in scar improvement with more physician and patients' satisfaction. Timolol, a beta-adrenergic receptor blocker, improves healing of skin wounds by increasing the phosphorylation of extracellular signal regulated kinases (ERK) leading to keratinocyte migration (Zeigler et al., 1999). Also, ERK initiate signaling cascades leading to fibroblast mitosis and proliferation with regulation of fibroblast functions in replacement of disorganized collagen and the reposition of the extracellular matrix (de Araújo et al., 2019). ;

Study Design

Related Conditions & MeSH terms

Acne Scars - Mixed Atrophic and Hypertrophic
Atrophy

Clinical Trial Details

NCT number	NCT05597813
Study type	Interventional
Source	Zagazig University
Contact
Status	Not yet recruiting
Phase	N/A
Start date	March 1, 2023
Completion date	November 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04559022` - Pilot Study Investigating the Efficacy of Fat Grafting as a Treatment for Male and Female Facial Acne Scarring	N/A
Active, not recruiting	`NCT06192550` - Functional Usability and Feasibility Testing of the Profound Matrix™ System	N/A
Recruiting	`NCT05362929` - Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color	N/A
Recruiting	`NCT05597267` - The MIRIA Acne Scar Study	N/A
Completed	`NCT05691049` - Evaluation of Efficacy and Safety of HCC_45 for the Correction of Acne Scars of the Face	N/A
Active, not recruiting	`NCT02592993` - Performance of PicoWayTM Picosecond Fractional Laser for Acne Scars	N/A
Completed	`NCT04827680` - Clinical Evaluation of the Safety and Performance of FRF for the Treatment and Reduction of Acne Scarring	N/A
Completed	`NCT03988049` - Comparison of 1,550 and 755 Laser in a Split-face Trial	N/A
Completed	`NCT03284333` - enLighten Laser With MLA Handpiece for Treatment of Moderate and Severe Acne Scars	N/A
Completed	`NCT03514771` - Early Non-Ablative Fractional Laser Resurfacing for Acne Scars After Treatment With Oral Isotretinoin	N/A
Not yet recruiting	`NCT06102343` - Safety and Efficacy Investigation on the Effects of ClearSkin Non-ablative ER:Glass 1540nm Laser Module in the Treatment of Acne Scars.	N/A
Not yet recruiting	`NCT05600075` - Microneedling With Topical Preparations in the Treatment of Atrophic Post-acne Scars	N/A
Not yet recruiting	`NCT04252352` - Treatment of Acne Scars With Fractional CO2 Laser Versus Radio-frequency Microneedling	N/A
Completed	`NCT04606134` - Tripeptide/Hexapeptide Topical and Hybrid Laser Treatment for Acne Scarring	N/A
Completed	`NCT05358860` - Safety and Efficacy of Sofwave Treatment for Acne Scars Appearance Improvement	N/A
Completed	`NCT04057768` - Fractional Radiofrequency for the Treatment and Reduction of Acne Scars and Wrinkles	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.