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Clinical Trial Summary

Primary Objectives - To assess the safety and tolerability of RGLS8429 - To assess the impact of RGLS8429 on ADPKD biomarkers Secondary Objectives - To assess the impact of RGLS8429 on height-adjusted total kidney volume (htTKV) - To characterize the pharmacokinetic (PK) properties of RGLS8429 - To assess the impact of RGLS8429 on renal function


Clinical Trial Description

In this randomized, double-blind, placebo-controlled Phase 1b study, multiple ascending doses of RGLS8429 or placebo will be administered via subcutaneous injection to subjects with ADPKD to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of RGLS8429. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05521191
Study type Interventional
Source Regulus Therapeutics Inc.
Contact Kristen Gillotti
Phone 858-202-6300
Email kgillotti@regulusrx.com
Status Recruiting
Phase Phase 1
Start date October 6, 2022
Completion date December 2023

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