The Ultrasonographic Changes of Intercostal Muscles and Diaphragm in Mechanically Ventilated Preterm Neonates

Mechanical Ventilation Complication Clinical Trial

Official title:

The Ultrasonographic Changes of Intercostal Muscles and Diaphragm in Mechanically Ventilated Preterm Neonates

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05495763
• Other study ID #: Noha ibrahim
• Status: Recruiting
• Start date: August 2022
• Est. completion date: January 2023

Study information

• Verified date: August 2022
• Source: Ain Shams University
• Contact: Noha Ibrahim, MB, BCh
• Phone: 01064099564
• Email: Nohasaied2000[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Invasive mechanical ventilation induces ventilator induced diaphragmatic dysfunction particularly when used for long time and Intercostal muscles as well contribute to the important work of respiratory movement by expanding the thorax , and determining the thickness of them would be a useful parameter in evaluating respiratory muscle activity.

This study will add the impact of mechanical ventilation on the diaphragm and intercostal muscles in preterm infants using ultrasound.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: January 2023
• Est. primary completion date: January 2023
• Gender: All
• Age group: 5 Minutes to 28 Days

Eligibility

Inclusion Criteria:

1. Preterm infants from 28-36 weeks gestation

2. In need for invasive mechanical ventilation according to work of breathing, oxygen saturation and blood gases .

Exclusion Criteria:

• 1) Significant congenital anomalies including cardiac, abdominal or respiratory.

2) Congenital anomalies involving the diaphragm. 3) Phrenic nerve paralysis. 4) Congenital muscular dystrophies. 5) Major upper or lower airway anomalies. 6) Storage diseases.

Related Conditions & MeSH terms

• Mechanical Ventilation Complication

Locations

Country	Name	City	State
Egypt	Ain Shams University	Cairo

Sponsors (1)

Lead Sponsor	Collaborator
Noha Saied Ibrahim

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The impact of mechanical ventilation on diaphragm and intercostal muscles using ultrasound	Using Ultrasound to measure Intercostal Muscles thickness and diaphragmatic thickness and excursion for assessing the impact of the mechanical ventilation on muscle power predicting weaning from ventilation.	6 months