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A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer

Colorectal Cancer Clinical Trial

Official title:
A Phase 1/2 Single Arm Open-Label Clinical Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer

Clinical Trial Summary

TC-510 is a novel cell therapy that consists of autologous genetically engineered T cells expressing two synthetic constructs: first, a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous T cell receptor (TCR) complex and second, a PD-1:CD28 switch receptor, which is expressed on the surface of the T cell, independently from the TCR. The PD-1:CD28 switch receptor comprises the PD-1 extracellular domain fused to the CD28 intracellular domain via a transmembrane domain. Thus, the switch is designed to produce a costimulatory signal upon engagement with PD-L1 on cancer cells.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Adenocarcinoma
  • Breast Neoplasms
  • Cholangiocarcinoma
  • Colorectal Cancer
  • Colorectal Neoplasms
  • Mesothelioma
  • Mesothelioma Peritoneum
  • Mesothelioma, Malignant
  • Mesotheliomas Pleural
  • Neoplasms
  • Non Small Cell Lung Cancer
  • Ovarian Adenocarcinoma
  • Ovarian Cancer
  • Ovarian Neoplasms
  • Ovarian Serous Adenocarcinoma
  • Pancreatic Adenocarcinoma
  • Pancreatic Cancer
  • Pancreatic Neoplasms
  • TNBC - Triple-Negative Breast Cancer
  • Triple Negative Breast Cancer
  • Triple Negative Breast Neoplasms
Clinical Trial Details
NCT number NCT05451849
Study type Interventional
Source TCR2 Therapeutics
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date June 21, 2022
Completion date October 30, 2028
View Details
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