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Clinical Trial Summary

Over the last decade, the use of mini-organ or organoids has been increasingly developed in fundamental research. Indeed, digestive organoids represent an essential advance compared to classical culture systems (epithelial cell lines, immortalized cells) since they preserve in culture the functional complexity present in vivo (architecture, different cell types). They also have the advantage of being able to be propagated indefinitely (unlike explants), minimizing the use of animal models and reducing the amount of tissue required. Finally, their growth and development depends on the origin of the sample (the organoid will develop differently if the cell source comes from a patient suffering from an inflammatory bowel disease, for example), thus generating models of human pathologies to better determine their physiopathology. The use of organoids in biomedical research has proven to be an indispensable tool for the understanding of cellular and molecular mechanisms involved in epithelial renewal and the screening of molecules and ingredients for applications in the health and agri-food sectors.


Clinical Trial Description

The project aims to generate a biocollection of 3D intestinal models from digestive biopsies with associated health data and to characterize them before using them for the screening of potential therapeutic molecules. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05294107
Study type Interventional
Source Rennes University Hospital
Contact Guillaume BOUGUEN, Professor
Phone 2 99 28 99 72
Email guillaume.bouguen@chu-rennes.fr
Status Recruiting
Phase N/A
Start date September 6, 2022
Completion date September 2024

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