Clinical Trials Logo

Clinical Trial Summary

This study is investigating the role of histamine in generating adaptation to exercise

Clinical Trial Description

Exercise promotes and maintains healthy cardiovascular, musculoskeletal, and metabolic function, but the signals and mechanisms which transduce these effects are poorly understood. Histamine plays a role in some of the positive benefits of exercise. The goal of this study is to determine the factors that regulate exercise's effects on endothelial and vascular function, with a focus on histamine released from mast cells in skeletal muscle. Participants will perform exercise or participate in interventions like heating that may replicate some of the effects of exercise. During most experiments, investigators will insert an intravenous catheter in an arm vein and microdialysis probes in the leg, collect dialysate from the microdialysis probe and blood from the vein, record noninvasive measures, and have the participants perform exercise or undergo heating. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05206227
Study type Interventional
Source University of Oregon
Contact John R Halliwill, PhD
Phone 541-600-4337
Status Recruiting
Phase Early Phase 1
Start date July 28, 2021
Completion date March 31, 2026

See also
  Status Clinical Trial Phase
Terminated NCT03313375 - Continuous vs Aerobic Postexercise Hypotension N/A
Completed NCT03112070 - Post-Exercise Hypotension After Water Exercise N/A