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Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding

Gastrointestinal Cancer Clinical Trial

Official title:
Endoscopic Treatment vs Transjugular Intrahepatic Portosystemic Shunt in the Management of Oxaliplatin Related Gastroesophageal Variceal Bleeding: A Multicenter, Randomized, Controlled Clinical Trial

Clinical Trial Summary

In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.

Clinical Trial Description

Oxaliplatin is used as the first-line chemotherapy for colorectal cancer. However, oxaliplatin-induced hepatotoxicity could lead to sinusoidal injury and portal hypertension in the long term. Variceal bleeding, as the most common complication of portal hypertension, threaten these patents' life. Endoscopic treatment and Transjugular Intrahepatic Portosystemic Shunt (TIPS) are both recommended management of gastroesophageal variceal bleeding. In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05141617
Study type Interventional
Source Shanghai Zhongshan Hospital
Contact Xiaoquan HUANG, M.D.
Phone 008618801733835
Email huang.xiaoquan@zs-hospital.sh.cn
Status Recruiting
Phase N/A
Start date November 3, 2021
Completion date December 31, 2023
View Details
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