| Eligibility |
Inclusion Criteria:
1. Age=18 years.
2. Patients with non-irradiable, non-operable, histologically or cytologically confirmed
Stage IIIB~IV NSCLC, harboring an EGFR exon 20 insertion mutation (including
duplication mutations), who have progressed on or intolerable to prior platinum-based
chemotherapy.
3. At least 1 measurable lesion according to RECIST 1.1.
4. ECOG score 0 or 1.
5. Life expectancy=3 months.
6. Adequate organ function(tested within 7 days prior to the first dose): Absolute
neutrophil count (ANC)=1.5×10^9 /L, Platelets=90×10^9/L, Hemoglobin=9 g/dL or =5.6
mmol/L; Serum creatinine <1.5 × ULN; Total bilirubin =1.5×ULN (if liver metastases are
present,=3×ULN), AST and ALT=3×ULN (if liver metastases are present,=5×ULN);INR or
PT=1.5×ULN, APTT=1.5×ULN.
7. A female of childbearing potential must have a negative serum pregnancy test within 7
days prior to the first dose. Any male and female patient of childbearing potential
must agree to use effective contraception method throughout the trial period and for
another half year after the end of the trial.
8. Fully understand and fully informed of this study; must sign and give the written
Informed Consent Form (ICF).
Exclusion Criteria:
1. Previously received monoclonal antibody therapy targeting EGFR.
2. Previous chemotherapy, biotherapy, targeted therapy, immunotherapy or other anti-tumor
treatment within 4 weeks prior to the first dose of the study drug, 2 weeks (or 5
half-lives whichever is longer) for using small molecule targeted drugs, 2 weeks for
using radiotherapy..
3. Treated with other investigational agents within 4 weeks prior to the first dose of
the study drug.
4. Experienced any major surgery (excluding puncture biopsy) or significant trauma within
4 weeks prior to the first dose.
5. Hypersensitivity or intolerance to our study drug or any excipients of the study drug.
6. Received strong or moderate inducers of CYP3A4 within 14 days prior to the first dose.
7. The adverse reactions of previous antitumor treatment have not yet recovered to Grade=
1 based on CTCAE 5.0 or baseline (except for the toxicity without safety risk judged
by the investigator, such as alopecia).
8. Had untreated central nervous system metastasis or meningeal metastasis.
9. History of autoimmune disease, immunodeficiency, including HIV positive, or the
presence of other acquired or congenital immunodeficiency, or organ transplantation.
10. Active hepatitis B, hepatitis C virus or syphilis infection.
11. History of severe cardiovascular disease.
12. Have difficulty with swallowing medications, or there is a condition seriously
affecting the gastrointestinal absorption as judged by investigators.
13. Other malignant tumors diagnosed within 5 years prior to the first dose, with the
exception of adequately treated skin basal cell carcinoma, skin squamous cell
carcinoma, preinvasive cervical carcinoma or breast cancer that was effectively
removed and not requiring or not expected to require other treatment during the study
period.
14. History of interstitial lung disease, drug-induced interstitial lung disease,
radioactive pneumonia requiring steroid treatment, or any evidence of clinical active
interstitial lung disease.
15. History of other serious systemic diseases, in the judgment of the investigator, that
make the subject unfit for the study.
16. Alcohol or drug dependence.
17. Had an unequivocal history of neurological or psychiatric disorders, including
epilepsy or dementia.
18. Pregnant or lactating woman.
19. Not suitable for this study as determined by the investigator due to other reasons.
20. Patients harboring EGFR exon20 insertion mutation and also have other EGFR
TKI-sensitizing EGFR mutations, such as G719X mutation in exon 18, exon 19 deletion
mutation (19 del), exon 20 T790M or S768I mutation, exon 21 L858R mutation, or L861Q
mutation.
21. Previously received drugs that developed for EGFR exon20 insertion mutated NSCLC (
such as TAK-788, Poziotinib, DZD9008 or JNJ-61186372); the short-term use is allowed,
such as=2 weeks. Responsive to previous EGFR-TKI treatment (including the best overall
response of complete response, partial response, or stable disease last more than 6
months). Previously received PD-1 or PD-L1 monoclonal antibody therapy within 3 months
prior to the first dose.
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