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Study of 2141-V11 in People With Non-muscle Invasive Bladder Cancer That Did Not Respond to Standard Treatment

Non-muscle Invasive Bladder Cancer Clinical Trial

Official title:
Phase I Study Evaluating the Safety and Tolerability of an Intravesical Anti-CD40 Agonist Antibody (2141-V11) in Subjects With Non-muscle Invasive Bladder Cancer Unresponsive to Bacillus Calmette-Guerin Therapy

Clinical Trial Summary

The purpose of this study is to test the safety of the study drug 2141-V11 in people whose NMIBC did not respond to standard treatment, and who will not have the standard surgical procedure to remove the bladder. The researchers will test different doses of 2141-V11 to see which dose is safest in people. The researchers will also do tests to see how the body absorbs, distributes, and gets rid of 2141-V11. This study is one of the first to test 2141-V11 in people, and the first to test 2141-V11 delivered through a catheter into the bladder.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05126472
Study type Interventional
Source Memorial Sloan Kettering Cancer Center
Contact Bernard Bochner, MD
Phone 646-422-4387
Email bochnerb@mskcc.org
Status Recruiting
Phase Phase 1
Start date November 8, 2021
Completion date November 2024
View Details
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