Real-world Evaluation of Brolucizumab for the Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) (Komodo Health)

Age-related Macular Degeneration (AMD) Clinical Trial

Official title: Real-world Evaluation of Brolucizumab for the Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD) (Komodo Health)

Status Completed

Clinical Trial Summary

This study was a retrospective cohort study of patients to assess the early insights into real-world safety among wet AMD patients initiating brolucizumab. Evidence was generated to describe their patient characteristics and clinical outcomes. The study was conducted using the Komodo Healthcare Map.

Clinical Trial Description

Komodo Healthcare Map claims data from 08-Oct-2016 to the date of most recent data from patients with wet AMD who initiated brolucizumab were analyzed in this study.

• Identification period of the index date (index period): The patients fulfilling the selection criteria were identified during the period from 08-Oct-2019 to 30-Apr-2020.

• Index date: Defined as the date of the earliest brolucizumab injection during the index period.

• Study Period: The period from 08-Oct-2016 to the most recent data extraction date (05-Jun-2020).

o Note since 05-Jun-2020 was the date data was pulled, claims data from recent months (e.g. May) may be incomplete (relative to the final DB state) as well.

• Pre-index period: The period 36 months prior to the index date

o Note: Data within 36 months prior to the index date will be used to assess baseline characteristics.

• Post-index period: The period of 180 days after the index date ;

Related Conditions & MeSH terms

• Age-related Macular Degeneration (AMD)
• Macular Degeneration

• NCT number: NCT05111743
• Study type: Observational
• Source: Novartis
• Status: Completed
• Start date: June 17, 2020
• Completion date: December 18, 2020