Microvascular Coronary Artery Disease Clinical Trial
— MACCUSOfficial title:
MACCUS: ModulAtion of Cardiac Coronary Sinus Hemodynamics to Develop a New Treatment for microvascUlar diseaSe. A Single Center, Randomized Study.
NCT number | NCT05034224 |
Other study ID # | 2021-4 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | August 23, 2021 |
Est. completion date | August 23, 2023 |
Verified date | August 2023 |
Source | Johannes Gutenberg University Mainz |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
MACCHUS is a randomized, single-center, controlled, cross-over interventional study in which coronary artery resistances will be measured at baseline and during temporary occlusion of the coronary sinus.
Status | Completed |
Enrollment | 20 |
Est. completion date | August 23, 2023 |
Est. primary completion date | August 23, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - Chronic coronary syndrome (including patients with anginal equivalents). - Reversible ischemia on non-invasive testing, indication to cardiac catheterization; - Indication to the assessment of microvascular function (note: patients will be asked for participation and consented prior to the first measurement of microvascular function, which will be conducted as per clinical indication; only those with evidence of pure or mixed microvascular disease (index of microvascular resistances (IMR)>25 will proceed into the study); - Willingness to participate and ability to understand, read and sign the informed consent; - Age>18 years Exclusion Criteria: - Previous CABG with patent grafts to the left anterior descending coronary - Epicardial coronary disease (FFR <0.80 with evidence of a focal stenosis) in the left anterior descending territory - Severe valvular heart disease - Any cardiomyopathy; pulmonary or renal disease - Inability to provide informed consent - Any disease reducing life expectancy |
Country | Name | City | State |
---|---|---|---|
Germany | Center of Cardiology, Cardiology I, university hospital Mainz | Mainz | Rheinland-Pfalz |
Lead Sponsor | Collaborator |
---|---|
Johannes Gutenberg University Mainz |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Index of microvascular resistances (balloon occlusion versus deflated balloon) | The Index of microvascular resistances, calculated as (Pressure distal - coronary venous pressure ) x mean transit time, will be compared between the two arms | 1 Minute after balloon occlusion |
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