Clinical Trials Logo
  1. Home
  2. Other
  3. NCT04908462

To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AL01211 in Healthy Volunteers

Autosomal Dominant Polycystic Kidney Clinical Trial

Official title:
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose in Healthy Volunteers and Autosomal Dominant Polycystic Kidney Disease Subjects Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral AL01211

Clinical Trial Summary

The study is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of Oral AL01211 in healthy volunteers

Clinical Trial Description

This study is a Phase 1, first in human (FIH), randomized, double-blind, placebo-controlled study of AL01211 in healthy adult participants The study consists of two parts: Part A will investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AL01211 in a single ascending dose escalation study in approximately 40 healthy adult participants. Part B will investigate the safety and tolerability, pharmacokinetics, and pharmacodynamics of AL01211 in a multiple ascending dose escalation study in approximately 40 healthy adult volunteers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04908462
Study type Interventional
Source AceLink Therapeutics, Inc.
Contact
Status Completed
Phase Phase 1
Start date June 8, 2021
Completion date June 20, 2022
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04310319 - Wishing to Decrease Aquaresis in ADPKD Patients Treated With a V2Ra; the Effect of Regulating Protein and Salt N/A
Recruiting NCT03596957 - Subacute Effect of Tolvaptan on Total Kidney Volume in Adult Patients With Autosomal Dominant Polycystic Kidney Disease Phase 4
Terminated NCT04064346 - Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycystic Kidney Disease Phase 3
Completed NCT03203642 - Study of the Efficacy and Safety of Tesevatinib in Subjects With ADPKD Phase 2
Recruiting NCT05500157 - Assessment of Treatment With Laparoscopic Fenestration or Aspiration Sclerotherapy for Large Symptomatic Hepatic Cysts N/A
Recruiting NCT04111692 - A Prospective Observational Study of Foam Sclerotherapy .
Recruiting NCT04907799 - Daily Caloric Restriction in ADPKD N/A
Completed NCT05401409 - Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease N/A
Terminated NCT03918447 - A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON Phase 3
Terminated NCT03749447 - An Extended Access Program for Bardoxolone Methyl in Patients With CKD (EAGLE) Phase 3
Recruiting NCT05228574 - Treatment of Vascular Stiffness in ADPKD Phase 4
Completed NCT03858439 - Dietary Intervention in ADPKD on Tolvaptan N/A
Recruiting NCT06391450 - Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease (EMPA-PKD) Phase 4
Recruiting NCT05478083 - A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver Disease Phase 2
Completed NCT03102632 - A Clinical Trial of Water Therapy for Autosomal Dominant Polycystic Kidney Disease N/A
Recruiting NCT05996731 - Developing a Pipeline to Employ RNA-Seq as a Complementary Diagnostic Tool in Rare Diseases N/A
Recruiting NCT06193616 - Outcome of ADPKD With Octreotide LAR
Completed NCT05646420 - Thyroid Hormones in ADPKD N/A
Completed NCT03366337 - A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIX Phase 2
Active, not recruiting NCT03273413 - Statin Therapy in Patients With Early Stage ADPKD Phase 4