Study on the Relationship Between Neutrophil-mediated Thrombocytopenia and the Condition and the Course of Disease in Patients With HFRS

Hemorrhagic Fever With Renal Syndrome Clinical Trial

Official title: Study on the Relationship Between Neutrophil-mediated Thrombocytopenia and the Condition and the Course of Disease in Patients With HFRS

Status Recruiting

Clinical Trial Summary

Thrombocytopenia is an important pathological feature of HFRS（Hemorrhagic Fever With Renal Syndrome, HFRS）. However, the cause of thrombocytopenia in HFRS is not yet fully understood. Neutrophils, as the largest number of white blood cells in the human body, can widely participate in the immune process of viral infections. Previous studies have found that the neutrophils of patients with acute myocardial infarction can interact with activated platelets and further mediate platelet phagocytosis.Therefore, this study aims to systematically elucidate the immunological process of neutrophil mediated thrombocytopenia in patients with HFRS by exploring the correlation between platelet activation, neutrophil activation and neutrophil proportion of adherent / phagocytic platelets peripheral blood of HFRS patients, and to analyze its relationship with the course of HFRS disease, which lays a theoretical foundation for further understanding the pathogenesis of HFRS and provides a basis for clinical use.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Hemorrhagic Fever With Renal Syndrome
• Thrombocytopenia

• NCT number: NCT04834713
• Study type: Observational
• Source: First Affiliated Hospital Xi'an Jiaotong University
• Contact: xiaojiao Li
• Phone: 0086-17521011271
• Email: lixiaojiao@xjtufh.edu.cn
• Status: Recruiting
• Start date: October 9, 2020
• Completion date: February 28, 2024