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Clinical Trial Summary

The purpose of this study is to observe and evaluate the efficacy and safety of pembrolizumab plus cisplatin and 5-fluorouracil (5-FU) followed Surgery for locally advanced adenocarcinoma of esophagogastric junction


Clinical Trial Description

The neoadjuvant chemotherapy/chemoradiotherapy with surgery is the standard treatment in NCCN guideline. But many patients refused or abandon radiotherapy because of the intolerable adverse effects. We designed a single-arm, open-label, phase II trial of pembrolizumab plus cisplatin and 5-fluorouracil (5-FU) followed by radical surgery for locally advanced adenocarcinoma of esophagogastric junction. The purpose of this study is to observe and evaluate the efficacy and safety. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04813523
Study type Interventional
Source Tianjin Medical University Cancer Institute and Hospital
Contact Hongjing Jiang, MD, PhD
Phone 8618622221069
Email jianghongjing@tmu.edu.cn
Status Recruiting
Phase Phase 2
Start date April 1, 2021
Completion date March 31, 2024

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