Hypermetabolism Due to Defect in Mitochondria Clinical Trial
Official title:
A Single Case Study of Hypermetabolism
| Verified date | December 2022 |
| Source | The Hospital for Sick Children |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Interventional |
In the Metabolic Disorder clinic at The Hospital for Sick Children, the investigators identified a male, proband with possible Luft's disease. The investigators hypothesize that Luft's disease is caused by excess or dysregulation of brown/beige fat tissue. To address the hypothesis, the investigators would like to assess brown fat distribution and activity in this subject.
| Status | Completed |
| Enrollment | 1 |
| Est. completion date | December 15, 2022 |
| Est. primary completion date | January 8, 2021 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 9 Years to 18 Years |
| Eligibility | Inclusion Criteria: - Diagnosis of hypermetabolism, possible Luft's disease. Exclusion Criteria: - None |
| Country | Name | City | State |
|---|---|---|---|
| Canada | The Hospital for Sick Children | Toronto |
| Lead Sponsor | Collaborator |
|---|---|
| The Hospital for Sick Children |
Canada,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Brown/beige fat tissue distribution and activity. Measurement tool- 18F FDG PET/CT (fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography) | Areas of 18F-FDG uptake on PET colocalizing with regions of fat will be identified on CT (-250to -10 Hounsfield Units) and quantified by Standard Uptake Value (SUV). | 1 day |