Effects of Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Clinical Trial

— LYMPHOARESIS  

Official title:

Comparison of the Effects of 2 Therapeutic Plasmapheresis Techniques: Single Plasma Exchange and Double Filtration Plasmapheresis (DFPP) on Peripheral Lymphocyte Phenotypes in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). A Monocentric Prospective Study With a Single-Case Experimental Design

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04742374
• Other study ID #: NIMAO/2020-01/OM001
• Status: Completed
• Phase: Early Phase 1
• Start date: February 1, 2021
• Est. completion date: February 3, 2022

Study information

• Verified date: July 2022
• Source: Centre Hospitalier Universitaire de Nimes
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

CIDP, a rare disorder affecting young adults, causes gradual weakness of the limbs, areflexia and impaired sensory function. New CIDP phenotypes without antibodies but with modified cell profiles have been described. Treatments include corticotherapy, IVIg and plasmapheresis but the latter's action mechanisms remain unclear. Plasmapheresis supposedly removes toxic agents like antibodies from plasma but it is uncertain whether it has an immune-modulating effect. Also, the refining mechanisms of the two main plasmapheresis techniques - single plasma exchange and double filtration plasmapheresis (DFPP) - are different and unclear. This study aims to compare the evolution of peripheral lymphocyte profiles in patients with CIDP according to their treatment (single centrifugation plasmapheresis or DFPP) to better grasp the action mechanisms of both techniques.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: February 3, 2022
• Est. primary completion date: February 3, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with confirmed Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) without pathogenic antibodies and stable under therapeutic plasmapheresis with one session every 2-3 weeks for at least two months.
• Patients who have given free written informed consent.
• Patients who have signed the consent form.
• Patients affiliated to or beneficiaries of a health insurance scheme.
• Adult patients (=18 ans).
• Healthy subjects of the same age and sex

Exclusion Criteria:

• Patients Under the age of 18.
• Patients under immunosuppressive treatment for less than 3 months.
• Patients participating in Category 1 research involving human subjects.
• Patients in an exclusion period determined by another study.
• Patients under legal protection, guardianship or curatorship.
• Patients unable to express consent.
• Patients for whom it is impossible to give informed information.
• Pregnant, parturient or breastfeeding patients.
• Healthy subject with chronic pathology or drug treatment

Related Conditions & MeSH terms

• Polyradiculoneuropathy
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Intervention

Biological:
• Blood sampling
Blood sampling before and after each type of cycle, Single Plasma Exchange or Double Filtration Plasmapheresis

Locations

Country	Name	City	State
France	Olivier MORANNE	Nîmes

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Nimes

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Group A, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Other	Group B, Cycle 1 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Other	Group A, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Other	Group B, Cycle 2 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Other	Group A, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Other	Group B, Cycle 3 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Other	Group A, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Other	Group B, Cycle 4 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Other	Group A, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Other	Group B, Cycle 5 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Other	Group A, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Other	Group B, Cycle 6 : Link between variations in lymphocyte sub-populations and the clinical evolution .	All the above primary and secondary outcome measures will be compared with clinical information in the patient file in order to determine a link between these variations at the end of each treatment cycle.	Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Other	Group A, Cycle 1 : Cost of single plasma exchange to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Other	Group B, Cycle 1 : Cost of double filtration plasmapheresis to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 1 (each cycle lasts 3 hours)
Other	Group A, Cycle 2 : Cost of double filtration plasmapheresis to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Other	Group B, Cycle 2 : Cost of single plasma exchange to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 2 (each cycle lasts 3 hours)
Other	Group A, Cycle 3 : Cost of single plasma exchange to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Other	Group B, Cycle 3 : Cost of double filtration plasmapheresis to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 3 (each cycle lasts 3 hours)
Other	Group A, Cycle 4 : Cost of double filtration plasmapheresis to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Other	Group B, Cycle 4 : Cost of single plasma exchange to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 4 (each cycle lasts 3 hours)
Other	Group A, Cycle 5 : Cost of single plasma exchange to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Other	Group B, Cycle 5 : Cost of double filtration to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 5 (each cycle lasts 3 hours)
Other	Group A, Cycle 6 : Cost of double filtration to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Other	Group B, Cycle 6 : Cost of double filtration to the health institution.	The cost of each cycle will be recorded in Euros in the electronic clinical research file and the average amount will be calculated from this information at the end of 6 cycles.	Day 7-10 after the end of Cycle 6 (each cycle lasts 3 hours)
Other	Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.	After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.	Day 0, Hour 0
Other	Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.	After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.	Day 0, Hour 3
Other	Constitution of a biological resource centre using the blood samples taken in view of future research, especially immunological phenotyping.	After all the above analyses, the unused aliquots from the samples taken (bottom of tubes) will be conserved and indexed.	Day 7-10
Other	Compare lymphocyte phenotype between patients with PIDC and control subjects.	Significant difference in Th1/Th2 ratio between PIDC patients and control subjects.	Day 0
Primary	Cycle 1, Group A : TH1 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Time 0
Primary	Cycle 1, Group A : TH1 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 1, Group A : TH1 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7 -10
Primary	Cycle 1, Group A : TH17 cells BEFORE first single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.	Day 0, Time 0
Primary	Cycle 1, Group A : TH17 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 1, Group A : TH17 cells 7 - 10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 peripheral lymphocyte cells will be measured in %.	Day 7 - 10
Primary	Cycle 1, Group A : T-reg cells BEFORE first single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 1, Group A : T-reg cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 1, Group A : T-reg cells 7 - 10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 7 - 10
Primary	Cycle 1, Group B : TH1 cells BEFORE first double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 1, Group B : TH1 cells AFTER the first double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 1, Group B : TH1 cells 7-10 days AFTER the first double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7 - 10
Primary	Cycle 1, Group B : TH17 cells BEFORE the first double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day0, Hour 0
Primary	Cycle 1, Group B : TH17 cells AFTER the first double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 1, Group B : T17 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 1, Group B : T-reg cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 1, Group B : T-reg cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 1, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 7 - 10
Primary	Cycle 2, Group A: TH1 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 2, Group A: TH1 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 2, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 cells will be measured in %.	Day 7 - 10
Primary	Cycle 2, Group A: TH17 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 2, Group A: TH17 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 2, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 2, Group A: T-reg cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 2, Group A: T-reg cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 2, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 7-10
Primary	Cycle 2, Group B: TH1 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 2, Group B: TH1 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 2, Group B: TH1 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.	Day 7-10
Primary	Cycle 2, Group B: T17 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 2, Group B: TH17 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 2, Group B: TH17 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 2, Group B: T-reg cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 2, Group B: T-reg cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 2, Group B: T-reg cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 7-10
Primary	Cycle 3, Group A: TH1 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 1, Hour 1
Primary	Cycle 3, Group A: TH1 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 1, Hour 3
Primary	Cycle 3, Group A: T1 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7 - 10
Primary	Cycle 3, Group A: TH17 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.	Day 1, Hour 1
Primary	Cycle 3, Group A: TH17 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 1, Hour 3
Primary	Cycle 3, Group A: TH17 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 7 - 10
Primary	Cycle 3, Group A: T-reg cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 3, Group A: T-reg cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 3, Group A: T-reg cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 7-10
Primary	Cycle 3, Group B: TH1 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 3, Group B: TH1 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 3, Group B: TH1 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7-10
Primary	Cycle 3, Group B: TH17 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 3, Group B: TH17 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 3, Group B: TH17 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 3, Group B: T-reg cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 3, Group B: T-reg cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 3, Group B: T-reg cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 7-10
Primary	Cycle 4, Group A: T1 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 4, Group A: T1 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 4, Group A: TH1 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7 - 10
Primary	Cycle 4, Group A: TH17 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 4, Group A: TH17 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 4, Group A: TH17 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 peripheral lymphocyte cells will be measured in %.	Day 7 - 10
Primary	Cycle 4, Group A: T-reg cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 4, Group A: T-reg cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 4, Group A: T-reg cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg peripheral lymphocyte cells will be measured in %.	Day 7 - 10
Primary	Cycle 4, Group B : TH1 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 4, Group B : TH1 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 4, Group B : TH1 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7 -10
Primary	Cycle 4, Group B : TH17 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 4, Group B : TH17 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 4, Group B : T17 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T1 peripheral lymphocyte cells will be measured in %.	Day 7 -10
Primary	Cycle 4, Group B : T-reg cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 4, Group B : T-reg cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 4, Group B : T-reg cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 7 - 10
Primary	Cycle 5, Group A : TH1 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 5, Group A : TH1 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 5, Group A : TH1 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 cells will be measured in %.	Day 7 - 10
Primary	Cycle 5, Group A : TH17 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 5, Group A : TH17 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 5, Group A : TH17 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 7 - 10
Primary	Cycle 5, Group A : T-reg cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 5, Group A : T-reg cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 5, Group A : T-reg cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 7 - 10
Primary	Cycle 5, Group B : TH1 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 5, Group B : TH1 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 5, Group B : TH1 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7-10
Primary	Cycle 5, Group B : TH17 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 5, Group B : TH17 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 5, Group B : TH17 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 5, Group B : T-reg cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 0
Primary	Cycle 5, Group B : T-reg cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0, Hour 3
Primary	Cycle 5, Group B : T-reg cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 7-10
Primary	Cycle 6, Group A : TH1 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0 Hour 0
Primary	Cycle 6, Group A : TH1 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0 Hour 3
Primary	Cycle 6, Group A : TH1 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7-10
Primary	Cycle 6, Group A : TH17 cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0 Hour 0
Primary	Cycle 6, Group A : TH17 cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 0 Hour 3
Primary	Cycle 6, Group A : TH17 cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 6, Group A : T-reg cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0 Hour 0
Primary	Cycle 6, Group A : T-reg cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 0 Hour 3
Primary	Cycle 6, Group A : T-reg cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and the number of T-reg cells will be measured in %.	Day 7-10
Primary	Cycle 6, Group B : TH1 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0 Hour 0
Primary	Cycle 6, Group B : TH1 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 0 Hour 3
Primary	Cycle 6, Group B : TH1 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH1 peripheral lymphocyte cells will be measured in %.	Day 7-10
Primary	Cycle 6, Group B : TH17 cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of TH17 cells will be measured in %.	Day 0 Hour 0
Primary	Cycle 6, Group B : TH17 cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 0 Hour 3
Primary	Cycle 6, Group B : TH17 cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of TH17 cells will be measured in %.	Day 7-10
Primary	Cycle 6, Group B : T-reg cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and the number of T-reg cells will be measured in %.	Day 0 Hour 0
Primary	Cycle 6, Group B : T-reg cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 0 Hour 3
Primary	Cycle 6, Group B : T-reg cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and the number of T-reg cells will be measured in %.	Day 7-10
Secondary	Cycle 1, Group A : T4 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : T4-DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : T8 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : B lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group A : T4 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : T4-DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : T8 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : T8 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : B lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : CD45RA-CCR7- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : CR6-CXCR3- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : T4-DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : B lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: T4 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: T4 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: T8 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: T8 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: B lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: CD45RA-CCR7- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B: CCR6-CXCR3- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 1, Group B:T4 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B:T4 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B:T8 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B:T8 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B: B lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B: CD45RA+CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B: CD45RA-CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B: CD45RA-CCR7- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B: CCR6-CXCR3- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 1, Group B: T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: B lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 1, Group B: CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube 7-10 days AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : B lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group A : T4 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) a,d measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : T8 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : B lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7 - 10
Secondary	Cycle 2, Group B : T4 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : T8 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : B lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 2, Group B : T4 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : T4 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : T8 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : T8 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : B lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : CD45RA-CCR7- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : CCR6-CXCR3- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 2, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : B lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 2, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured a percentage.	Day 7-10
Secondary	Cycle 2, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : T4 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : T8 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : B lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : CC45RA+CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : CC45RA-CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : CC45RA-CCR7- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group A : T4 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : T4 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : T8 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : T8 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : B lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : CD45RA-CCR7- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : CCR6-CXCR3- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : T4 lymphocytes 7 -10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : B lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : B lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 3, Group B : T4 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : T8 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : B lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 3, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 3, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : B lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group A : T4 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : T8 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : B lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : T4 lymphocytes BEFORE plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : T4 DR+ lymphocytes BEFORE plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : T8 lymphocytes BEFORE plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : B lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 0
Secondary	Cycle 4, Group B : T4 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : T4 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : T8 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : T8 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : B lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : CD45RA-CCR7- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : CCR6-CXCR3- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0 Hour 3
Secondary	Cycle 4, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : B lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 4, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : T4 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : T4 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : T8 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : T8 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : B lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : CD45RA+CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : CD45RA-CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : CD45RA-CCR7- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : CCR6-CXCR3- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group A : T4 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : T4 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : T8 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : T8 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : B lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : CD45RA+CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : CD45RA-CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : CD45RA-CCR7- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : CCR6-CXCR3- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group A : T4 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : T8 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : B lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group A : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : T4 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : T8 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : B lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 5, Group B : T4 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : T4 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : T8 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : T8 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : B lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : CD45RA-CCR7- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : CCR6-CXCR3- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 5, Group B : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : B lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 5, Group B : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : T4 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : T4 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : T8 lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : T8 DR+ lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : B lymphocytes BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : CD45RA+CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : CD45RA-CCR7+ cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : CD45RA-CCR7- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : CCR6-CXCR3- cells BEFORE double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube BEFORE double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 0
Secondary	Cycle 6, Group A : T4 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : T4 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : T8 lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : T8 DR+ lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : B lymphocytes AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : CD45RA+CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : CD45RA-CCR7+ cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : CD45RA-CCR7- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : CCR6-CXCR3- cells AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, Hour 3
Secondary	Cycle 6, Group A : T4 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : T4 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : T8 lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : T8 DR+ lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : B lymphocytes 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : CD45RA+CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : CD45RA-CCR7+ cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : CD45RA-CCR7- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group A : CCR6-CXCR3- cells 7-10 days AFTER double filtration plasmapheresis	5 mL of blood will be collected in an EDTA tube AFTER double filtration plasmapheresis and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : T4 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : T4 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : T8 lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : T8 DR+ lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : B lymphocytes BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : CD45RA+CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : CD45RA-CCR7+ cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : CD45RA-CCR7- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : CCR6-CXCR3- cells BEFORE single plasma exchange	5 mL of blood will be collected in an EDTA tube BEFORE single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H0
Secondary	Cycle 6, Group B : T4 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : T4 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : T8 lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : T8 DR+ lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : B lymphocytes AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : CD45RA+CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : CD45RA-CCR7+ cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : CD45RA-CCR7- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : CCR6-CXCR3- cells AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 0, H3
Secondary	Cycle 6, Group B : T4 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : T4 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : T8 lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : T8 DR+ lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : B lymphocytes 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : CD45RA+CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : CD45RA-CCR7+ cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : CD45RA-CCR7- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10
Secondary	Cycle 6, Group B : CCR6-CXCR3- cells 7-10 days AFTER single plasma exchange	5 mL of blood will be collected in an EDTA tube AFTER single plasma exchange and cell counts will be made by flow cytometry after marking with specific fluorescent antibodies (Luminex) and measured as a percentage.	Day 7-10