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Clinical Trial Summary

The purpose of this study is to learn about the feasibility and safety of using Peptide Receptor Radionuclide Therapy (PRRT) before and after surgical removal of a tumor. PRRT treatment is based on the administration of a radioactive product, 177-Lu DOTA-0-Tyr3-Octreotate (Lutathera®) and its use before and after surgery is thought to increase the overall survival benefit for patients with SSTR-positive gastroenteropancreatic neuroendocrine tumors GEP-NETs.


Clinical Trial Description

Primary Objective(s) - To assess feasibility and safety of combination of perioperative 177Lu Dotatate and cytoreductive surgery in metastatic GEP NETs Secondary Objective(s) - To assess response rate (RR) after 2 cycles 177Lu Dotatate - To assess recurrence free survival (RFS) of the overall treatment strategy - To assess overall survival (OS) of the overall treatment strategy ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04609592
Study type Interventional
Source Stanford University
Contact Gino Pinedo
Phone 650-725-8474
Email gpineda@stanford.edu
Status Recruiting
Phase Phase 1
Start date March 17, 2021
Completion date September 2027

See also
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Completed NCT03017690 - Lanreotide and Octreotide Long Acting Release (LAR) for Patients With Advanced Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)