Adult Patients With Lesions on Fingers or Toes Clinical Trial
— ACROCOVIDOfficial title:
Clinical and Mechanistic Study of Patients With a Recent Acrosyndrome
The recent and unexpected occurrence of patients with the development of skin lesions on the hands and/ or feet has been described recently. As these cases occurred contemporaneously with the Coronavirus Disease 2019 (COVID-19) and as it was the most often occurrence of de novo frostbites, the question raised of whether there is a direct link between the occurrence of these lesions and infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) the responsible for CoVID-19. Indeed, mechanisms of these lesions and the precise correlation with Sars-CoV-2 remains poorly understood. Therefore, this study aim to: 1. Determine the possible link with this virus, 2. Understand the mechanisms involved in the pathogenesis of these lesions.
Status | Not yet recruiting |
Enrollment | 25 |
Est. completion date | March 2023 |
Est. primary completion date | March 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Adult patients - Consultant for the recent occurrence of lesions on the fingers and or toes - Having signed an informed consent - Affiliated or entitled to a social security regime Exclusion Criteria: - Patients under guardianship or under curate - Patients under state medical assistance |
Country | Name | City | State |
---|---|---|---|
France | Department of Dermatology, Tarnier hospital, AP-HP | Paris |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris | Institut Cochin |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Detection of SARS-CoV-2 by real-time PCR and serological test | SARS-CoV-2 will be tested by Polymorphism Chain Reaction (PCR) (on the first day of consultation) and serological analysis ( at day 0 and day 15 after the first consultation) | assessing change between day 0 and day 15 | |
Secondary | Detection of SARS-CoV-2 by metagenomics analysis | Metagenomics analysis will be performed on nasopharyngeal, tonsil and perianal samples | Up to 2.5 months after inclusion | |
Secondary | Detection of acrosyndrome by transcriptomic analysis of skin samples | Transcriptomic analysis will be conducted with RNA extracted from frozen skin samples | Up to 2.5 months after inclusion |