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Clinical Trial Summary

The purpose of this study is to determine the efficacy and safety of Ruxolitinib and Decitabine intensified Conditioning Regimen in Patients with High Risk hematological malignancies undergoing allogeneic peripheral blood stem cell transplantation.


Clinical Trial Description

Allogeneic hematopoietic stem cell transplantation should be offered to eligible patients with high risk hematological malignancies whenever feasible. To further improve the outcome of transplantation patients with high risk hematological malignancies, the investigators developed a modified Bu/Cy conditioning regimen intensified by Ruxolitinib and Decitabine. In this study, the investigators tested the efficacy and feasibility of the modified Bu/Cy conditioning regimen intensified by Ruxolitinib and Decitabine in Patients with high risk hematological malignancies undergoing allogeneic peripheral blood stem cell transplantation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04582604
Study type Interventional
Source Chinese PLA General Hospital
Contact Daihong Liu
Phone 86-13681171597
Email daihongrm@163.com
Status Recruiting
Phase Phase 1/Phase 2
Start date September 1, 2020
Completion date September 30, 2025

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